Journal
TALANTA
Volume 201, Issue -, Pages 455-459Publisher
ELSEVIER
DOI: 10.1016/j.talanta.2019.04.051
Keywords
Chemiluminescence; Chitosan hydrogels; ROS; Imaging
Categories
Funding
- Natural Science Foundation of Jiangsu Province [BK20181331]
- National Natural Science Foundation of China [NSFC 81671745]
- Qinglan Project of Jiangsu Province (2018)
- Double First-ClassUniversity project [CPU2018GY38, CPU2018GY24]
Ask authors/readers for more resources
Chemiluminescence probes have been widely used in a very broad field including immunoassay or non-immunoassay diagnostic and monitoring techniques as well as biosensors. The luminol analog L012 as a chemiluminescence probe was applied in the detection of reactive oxygen species (ROS). However, the short chemiluminescence time of L012 limits its application in imaging in vivo. In this study, we developed chemiluminescence chitosan hydrogels L012-Cs-Co2+ based on a slow-diffusion-controlled heterogeneous catalytic mechanism. The hydrogels can emit strong chemiluminescence in the presence of H2O2, which can be observed by naked eyes in the darkroom within 60 min. They also exhibited high sensitivity towards H2O2 with the calculated detection limit of 8.7 x 10(-8) M. In addition, it was successfully applied in imaging of H2O2 in vivo.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available