Journal
SYNLETT
Volume 30, Issue 18, Pages 2041-2050Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0037-1611905
Keywords
thiadiazoles; cyclization; sulfur; multicomponent reaction
Categories
Funding
- National Natural Science Foundation of China [21572025, 21602019, 21672028]
- Innovation & Entrepreneurship Talents Introduction Plan of Jiangsu Province
- Natural Science Foundation of Jiangsu Province [BK20171193]
- Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology [BM2012110]
- Advanced Catalysis and Green Manufacturing Collaborative Innovation Center
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Thiadiazole moieties are present in many natural products and pharmaceutical compounds that possess a broad spectrum of biological activities, serving as antidepressant, anxiolytic, antimicrobial, antitubercular, antiinflammatory, antidiabetic, anticancer, antihypertensive, or antifungal drugs. Many excellent methods have been reported for accessing such frameworks. In this review, we summarize advances made within the past ten years in the synthesis of various types of thiadiazole. 1 Introduction 2 Synthesis of Thiadiazoles 2.1 Synthesis of 1,2,3-Thiadiazoles 2.1.1 Synthesis of 1,2,3-Thiadiazoles from Diazo/Azide Compounds 2.1.2 Synthesis of 1,2,3-Thiadiazoles from Sulfonyl Hydrazines or N -Tosylhydrazones 2.2 Synthesis of 1,2,4-Thiadiazoles 2.2.1 Synthesis of 1,2,4-Thiadiazoles from Thioamides or their Derivatives 2.2.2 Synthesis of 1,2,4-Thiadiazoles from Amidines or 2-Aminopyridines 2.3 Synthesis of 1,3,4-Thiadiazoles 2.4 Synthesis of 1,2,5-Thiadiazoles 3 Conclusion
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