Journal
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
Volume 30, Issue 5, Pages 563-575Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.beem.2016.07.002
Keywords
miRNA-guided diagnostics; miRNA; microRNA; biomarkers; detection methods; clinical decision-making
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Funding
- Southeastern Ontario Academic Medical Association
- Department of Pathology and Molecular Medicine at Queen's University
- Canada Foundation for Innovation John R. Evans Leaders Fund
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miRNA-guided diagnostics is a powerful molecular approach for evaluating clinical samples through miRNA detection and/or visualization. To date, this approach has been successfully used to diagnose, manage, and/or monitor a wide range of neoplastic and non-neoplastic diseases. Despite the promise of miRNA-guided diagnostics, particularly in the field of minimally invasive biomarkers, several knowledge and practical issues confound or hinder translation into routine clinical practice including: miRNA sequence database errors, suboptimal RNA extraction methods, detection assay variability, a vast array of online resources for bioinformatic analyses, and non-standardized statistical analyses for miRNA clinical testing. In this review, we raise awareness of these issues and recommend research directions to help specialists in endocrinology and metabolism integrate miRNA testing into clinical decision-making. (C) 2016 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license.
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