Journal
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
Volume 30, Issue 4, Pages 487-496Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.beem.2016.08.002
Keywords
brown adipose tissue; brown adipocytes; beige adipocytes; lipoprotein metabolism; triglycerides; BAT regulation
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Funding
- EU FP7 project RESOLVE [FP7-HEALTH-305707]
- MD/PhD fellowship of the University Medical Center Hamburg Eppendorf
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Excess and ectopic fat accumulation in obesity is a major risk factor for developing hyperlipidemia, type 2 diabetes and cardiovascular disease. The activation of brown and/or beige adipocytes is a promising target for the treatment of metabolic disorders as the combustion of excess energy by these thermogenic adipocytes may help losing weight and improving plasma parameters including triglyceride, cholesterol and glucose levels. The regulation of heat production by thermogenic adipose tissues is based on a complex crosstalk between the autonomous nervous system, intracellular and secreted factors. This multifaceted alignment regulates thermogenic demands to environmental circumstances in dependence on available energy resources. This review summarizes the current knowledge how thermogenic tissues can be targeted to combat the burden of diseases with a special focus on lipid metabolism and diseases related to lipoprotein metabolism. (C) 2016 Elsevier Ltd. All rights reserved.
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