Journal
STEM CELLS
Volume 38, Issue 1, Pages 22-33Publisher
OXFORD UNIV PRESS
DOI: 10.1002/stem.3079
Keywords
bioenergetics; cell-based therapies; cell delivery and transplantation; cell survival; mesenchymal stem cells; metabolism; multipotent stromal cells; skeletal stem cells; tissue engineering and regenerative medicine
Categories
Funding
- China Scholarship Council [201600160067]
- L'Agence Nationale de la Recherche [ANR-12-BSV5-0015-01, ANR-16-ASTR-0012-01]
- Agence Nationale de la Recherche (ANR) [ANR-12-BSV5-0015] Funding Source: Agence Nationale de la Recherche (ANR)
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In tissue engineering and regenerative medicine, stem cell-specifically, mesenchymal stromal/stem cells (MSCs)-therapies have fallen short of their initial promise and hype. The observed marginal, to no benefit, success in several applications has been attributed primarily to poor cell survival and engraftment at transplantation sites. MSCs have a metabolism that is flexible enough to enable them to fulfill their various cellular functions and remarkably sensitive to different cellular and environmental cues. At the transplantation sites, MSCs experience hostile environments devoid or, at the very least, severely depleted of oxygen and nutrients. The impact of this particular setting on MSC metabolism ultimately affects their survival and function. In order to develop the next generation of cell-delivery materials and methods, scientists must have a better understanding of the metabolic switches MSCs experience upon transplantation. By designing treatment strategies with cell metabolism in mind, scientists may improve survival and the overall therapeutic potential of MSCs. Here, we provide a comprehensive review of plausible metabolic switches in response to implantation and of the various strategies currently used to leverage MSC metabolism to improve stem cell-based therapeutics. Stem Cells 2019
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