Journal
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
Volume 220, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.saa.2019.117140
Keywords
Dipeptide; Fluorescent chemosensor; Zinc ions; Na(2)EDTA; Biological imaging
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Funding
- Fundamental Research Funds of China West Normal University [416628/18B018]
- Doctoral Scientific Research Start-up Foundation of China West Normal University [412662/17E048]
- Major project funds of Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province [CSPC2018ZD03]
- Science and Technology Planning Project of Qing-Hai Department of Science and Technology [2018-ZJ-919]
- Application Foundation Project of Department of Science and Technology of Sichuan Province [2018JY0115]
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This paper describes a new fluorescent chemosensor (DSH) based on dipeptide conjugated with dansyl group, which was synthesized by solid phase peptide synthesis (SPPS) technology. DSH exhibited a highly selective and sensitive toward Zn2+ ions by turn-on response based on generation of monomer-excimer mechanism in aqueous solutions, and the detection limit was calculated at 11.2 nM. In addition, the reversible of DSH-Zn with Na(2)EDTA establishes the reuse of DSH, and the circulation effect was very good. Moreover, DSH had good water solubility, and was successfully applied to bioimage intracellular Zn2+ ions and Na(2)EDTA in two different living cells with exciting cellular permeability and low cytotoxicity, which indicated that DSH had great potential in the application of biological imaging. (C) 2019 Elsevier B.V. All rights reserved.
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