Journal
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
Volume 12, Issue -, Pages 2776-2783Publisher
BEILSTEIN-INSTITUT
DOI: 10.3762/bjoc.12.276
Keywords
3D printing; digitising chemistry; ibuprofen; laboratory robotics; open source; reaction ware
Categories
Funding
- EPSRC [EP/H024107/1, EP/I033459/1, EP/J00135X/1, EP/J015156/1, EP/K021966/1, EP/K023004/1, EP/K038885/1, EP/L015668/1, EP/L023652/1]
- ERC [670467 SMART-POM]
- Royal-Society Wolfson Foundation
- [318671]
- EPSRC [EP/L015668/1, EP/K038885/1, EP/P00153X/1, EP/K021966/1, EP/K023004/1, EP/L023652/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/L015668/1, EP/K021966/1, EP/P00153X/1, EP/K038885/1, EP/K023004/1, EP/L023652/1] Funding Source: researchfish
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An automated synthesis robot was constructed by modifying an open source 3D printing platform. The resulting automated system was used to 3D print reaction vessels (reactionware) of differing internal volumes using polypropylene feedstock via a fused deposition modeling 3D printing approach and subsequently make use of these fabricated vessels to synthesize the nonsteroidal anti-inflammatory drug ibuprofen via a consecutive one-pot three-step approach. The synthesis of ibuprofen could be achieved on different scales simply by adjusting the parameters in the robot control software. The software for controlling the synthesis robot was written in the python programming language and hard-coded for the synthesis of ibuprofen by the method described, opening possibilities for the sharing of validated synthetic 'programs' which can run on similar low cost, user-constructed robotic platforms towards an 'open-source' regime in the area of chemical synthesis.
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