Journal
SMALL
Volume 15, Issue 39, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201902313
Keywords
antibiotic penetration; biofilm channels; biofilm eradication; gentamicin; iron-oxide nanoparticles
Categories
Funding
- National Key Research and Development Program of China [2016YFC1100402]
- National Natural Science Foundation of China [21334004, 11574222, 21522404]
- UMCG, Groningen, The Netherlands
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The poor penetrability of many biofilms contributes to the recalcitrance of infectious biofilms to antimicrobial treatment. Here, a new application for the use of magnetic nanoparticles in nanomedicine to create artificial channels in infectious biofilms to enhance antimicrobial penetration and bacterial killing is proposed. Staphylococcus aureus biofilms are exposed to magnetic-iron-oxide nanoparticles (MIONPs), while magnetically forcing MIONP movement through the biofilm. Confocal laser scanning microscopy demonstrates artificial channel digging perpendicular to the substratum surface. Artificial channel digging significantly (4-6-fold) enhances biofilm penetration and bacterial killing efficacy by gentamicin in two S. aureus strains with and without the ability to produce extracellular polymeric substances. Herewith, this work provides a simple, new, and easy way to enhance the eradication of infectious biofilms using MIONPs combined with clinically applied antibiotic therapies.
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