Journal
SENSORS AND ACTUATORS B-CHEMICAL
Volume 295, Issue -, Pages 179-185Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2019.05.088
Keywords
Ion mobility spectrometry; Sensitivity; Non-uniform electrostatic field; Ion enrichment; SIMION simulation
Funding
- National Key R&D Program of China [2016YFC0201200, 2016YFC0800902]
- National Natural Science Foundation of China [21405158]
- Dalian Institute of Chemical Physics [DICP ZZBS201709, DICP ZZBS201801]
- Scientific Study Project of Liaoning Province Educational Commission of China [LQ201715001]
- CAS President's International Fellowship Initiative [2019VEA0033]
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The diversified applications of ion mobility spectrometry (IMS) frequently pose challenges to the sensitivity of IMS measurements. In this work, the ion density evolution profiles of a continuous flow of ions travelling in nonuniform electrostatic fields were studied. Based on that, an ion enrichment method was proposed for enhancing the sensitivity of IMS. It employed a gradually weakening electrostatic field in the ionization region of IMS and achieved ion density enhancement for the ion flow migrating from the ion source to the ion shutter. Using that method, the ion density of the ion flow produced by the ion source was increased by 180% when approaching the ion shutter. With the increased ion density, the limit of detection (LOD) for DMMP dimer peak was lowered from 425 to 200 pptv. Meanwhile, there was a slight reduction in the resolving power, which was tentatively assigned to the enhanced coulomb repulsion along with the increased ion density. The resolving power of the IMS with a drift length of 60mm was still maintained around 80 at 100 degrees Celsius. The ion enrichment method needs no radial-confining radio frequency voltage. Also, it does not affect the response speed of IMS.
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