Journal
BEHAVIOURAL PHARMACOLOGY
Volume 27, Issue 8, Pages 689-696Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/FBP.0000000000000248
Keywords
depression; intranasal administration; neonatal maternal deprivation; neurogenesis rat; oxytocin
Funding
- Natural Science Foundation of Shandong Province [ZR2014HP069]
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Oxytocin( OT), a hypothalamic neuropeptide, has been implicated in the regulation of social behaviors in rodents and humans. This study assessed the effects of intranasal administration of OT on depressive-like behaviors and hippocampal neurogenesis in adult rats following neonatal maternal deprivation( NMD). Here, we show that NMD resulted in significant depression-like behaviors, as indicated by decreases in physical activity and emotional reactivity in a novel environment, in 2-month-old animals. Notably, the OT levels in the plasma, hypothalamus, and hippocampus were decreased in these animals. Intranasal administration of OT reduced the depressive-like behaviors in NMD rats and rescued hippocampal long-term plasticity impaired by NMD stress in rats by promoting hippocampal neurogenesis. These results indicate that OT alleviates the depressive-like behaviors in NMD adult rats, probably mediated by improving adult hippocampal neurogenesis. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.
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