Journal
SCIENCE
Volume 365, Issue 6460, Pages 1475-+Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aax5415
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Funding
- Robert A. Welch Foundation [C-1664, C-1787]
- National Science Foundation [CHE1507745, CHE1903980, 1842494]
- Smalley-Curl Institute at Rice University
- Gordon and Betty Moore Foundation
- SLAC National Accelerator Laboratory
- Stanford School of Medicine
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Plasmon-coupled circular dichroism has emerged as a promising approach for ultrasensitive detection of biomolecular conformations through coupling between molecular chirality and surface plasmons. Chiral nanoparticle assemblies without chiral molecules present also have large optical activities. We apply single-particle circular differential scattering spectroscopy coupled with electron imaging and simulations to identify both structural chirality of plasmonic aggregates and plasmon-coupled circular dichroism induced by chiral proteins. We establish that both chiral aggregates and just a few proteins in interparticle gaps of achiral assemblies are responsible for the ensemble signal. but single nanoparticles do not contribute. We furthermore find that the protein plays two roles: It transfers chirality to both chiral and achiral plasmonic substrates. and it is also responsible for the chiral three-dimensional assembly of nanorods. Understanding these underlying factors paves the way toward sensing the chirality of single biomolecules.
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