Journal
SCIENCE
Volume 365, Issue 6455, Pages 813-+Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aav5427
Keywords
-
Categories
Funding
- DELTAS Africa Initiative, an independent funding scheme of the African Academy of Sciences (AAS)'s Alliance for Accelerating Excellence in Science in Africa (AESA)
- New Partnership for Africa's Development Planning and Coordinating Agency (NEPAD Agency)
- Wellcome (DELGEME grant) [107740/Z/15/Z]
- U. K. government
- Armed Forces Health Surveillance Center (AFHSB) and its Global Emerging Infections Surveillance (GEIS) Section [P0209_15_KY]
- Wellcome [206194, 090770/Z/09/Z]
- MRC Centre for Genomics and Global Health - Medical Research Council [G0600718, M006212]
- MRC Centre for Genomics and Global Health - Department for International Development (DFID) [G0600718, M006212]
- MRC [MC_EX_MR/K02440X/1, MR/M006212/1, G0600718] Funding Source: UKRI
- Wellcome Trust [090770/Z/09/Z, 107740/Z/15/Z] Funding Source: Wellcome Trust
Ask authors/readers for more resources
Understanding genomic variation and population structure of Plasmodium falciparum across Africa is necessary to sustain progress toward malaria elimination. Genome clustering of 2263 P. falciparum isolates from 24 malaria-endemic settings in 15 African countries identified major western, central, and eastern ancestries, plus a highly divergent Ethiopian population. Ancestry aligned to these regional blocs, overlapping with both the parasite's origin and with historical human migration. The parasite populations are interbred and shared genomic haplotypes, especially across drug resistance loci, which showed the strongest recent identity-by-descent between populations. A recent signature of selection on chromosome 12 with candidate resistance loci against artemisinin derivatives was evident in Ghana and Malawi. Such selection and the emerging substructure may affect treatment-based intervention strategies against P. falciparum malaria.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available