Journal
RUSSIAN JOURNAL OF GENERAL CHEMISTRY
Volume 89, Issue 8, Pages 1673-1682Publisher
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S1070363219080218
Keywords
piperidinone; pyrimidine; thiazolopyrimidine; diazipine; oxatriazine; thiazole; anticancer; HCT-116; MCF-7
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New piperidinone incorporating pyrimidine, triazine, diazipine, oxatriazine, and thiazole derivatives have been synthesized starting with tetramethylpipridin-4-one. Structures of the newly synthesized compounds are characterized on the basis of spectroscopic and analytical data. The anticancer activity of the prepared compounds has been studied in vitro against HCT-116 and MCF-7 human cancer cells using the MTT assay. A number of compounds demonstrates potent activity towards both cell lines with IC50 values comparable with doxorubicin.
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