Journal
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
Volume 29, Issue 6, Pages 739-743Publisher
SOC BRASILEIRA FARMACOGNOSIA
DOI: 10.1016/j.bjp.2019.08.004
Keywords
Lauraceae; Flavonol glycoside; Megastigmane glycosides; Lignans
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Funding
- Technology Innovation Program - Ministry of Trade, Industry & Energy (MOTIE, Korea) [10080691]
- Korea Evaluation Institute of Industrial Technology (KEIT) [10080691] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Persea americana Mill., Lauraceae, commonly known as the avocado, is native to tropical and subtropical regions, including Brazil. From the leaves of P. americana, one previously undescribed flavonol glycoside (1) together with ten known flavonoids (2-11), four megastigmane glycosides (12-15) and two lignans (16-17) were isolated. Their structures were determined by extensive spectroscopic methods including 1D- and 2D-nuclear magnetic resonance and mass spectrometry data. This is the first investigation that reports megastigmane glycoside and lignan classes within the genus Persea. All the isolated compounds have been assessed through the cell survival of larval zebrafish following neomycin-induced damage and the cell viability of a House Ear Institute-Organ of Corti 1 mouse auditory cell line. Among the tested compounds, juglanin (2) and (+)-lyoniresinol (16) showed significant cell regeneration in neomycin-damaged hair cell without cellular toxicity. (C) 2019 Published by Elsevier Editora Ltda. on behalf of Sociedade Brasileira de Farmacognosia.
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