Journal
RESEARCH ON CHEMICAL INTERMEDIATES
Volume 46, Issue 1, Pages 283-297Publisher
SPRINGER
DOI: 10.1007/s11164-019-03949-3
Keywords
Schiff base; Metal complexes; Carbonic anhydrase; Antioxidant activity; Enzyme inhibition; XRD analysis
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Considering the importance of metal complexes in the development of medical science, two different Schiff base Fe(II) and Co(II) metal complex compounds were synthesized with Schiff base obtained through the condensation of 1-(4-aminophenyl)ethanone with 2-hydroxy-3-methoxybenzaldehyde. The reactions of the ligand with Co(II) and Fe(II) metal ions enabled six coordination compounds with octahedral geometries. The novel metal complexes were characterized by IR, elemental analyses, magnetic susceptibility, mass spectra, UV-Vis, thermogravimetry-differential thermal analysis (TGA-DTA) and X-ray diffraction analysis. The antioxidant properties of the new compounds were investigated using different in vitro assays. Moreover, enzyme inhibition of derivatives complexes against carbonic anhydrase I and II isoenzymes (CA I and II) and acetylcholinesterase (AChE) was evaluated. The best inhibitor complex for CA I and II isoenzymes was the Fe(II) complex with K-i values of 52.83 +/- 11.52 and 63.34 +/- 8.88, respectively.
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