Journal
REGENERATIVE MEDICINE
Volume 14, Issue 9, Pages 831-840Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/rme-2019-0040
Keywords
autologous PRP; degenerative disc disease; intervertebral disc degeneration; long-term outcomes
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Funding
- NCATS of the NIH [UL1TR002384]
- Clinical Translational Science Center, National Center for Advancing Translational Science [UL1-RR024996]
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Aim: This study assessed pain and function at 5-9 years postinjection in a subset of patients who received intradiscal platelet-rich plasma (PRP) injections for moderate-to-severe lumbar discogenic pain. Patients & methods: All patients received injections of intradiscal PRP in a previous randomized controlled trial. Data on pain, function, satisfaction, and need for surgery were collected at one time point of 5-9 years postinjection and compiled with existing data. Results: In comparison to baseline, there were statistically significant improvements in pain and function (p < 0.001). All improvements were clinically significant. Six patients had undergone surgery during the follow-up period. Conclusion: This subset of patients demonstrated statistically and clinically significant improvements in pain and function at 5-9 years postinjection.
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