Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 116, Issue 34, Pages 16729-16735Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1908761116
Keywords
supramolecular coordination complexes; metallacycle; chemo-photothermal synergistic therapy; the second near-infrared channel; melanin dots
Categories
Funding
- National Key RD Program [2017YFA0505203]
- NIH [R01 CA215157, 1R01GM128037]
- National Natural Science Foundation of China [21708012, 21702079]
- Central China Normal University from the colleges, basic research and operation of Ministry of Education [110030106190234]
- Wuhan Morning Light Plan of Youth Science and Technology [201705304010321]
- NSF [CHE-1506722]
- South-Central University for Nationalities
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Discrete Pt(II) metallacycles have potential applications in biomedicine. Herein, we engineered a dual-modal imaging and chemophotothermal therapeutic nano-agent 1 that incorporates discrete Pt(II) metallacycle 2 and fluorescent dye 3 (emission wavelength in the second near-infrared channel [NIR-II]) into multifunctional melanin dots with photoacoustic signal and photothermal features. Nano-agent 1 has a good solubility, biocompatibility, and stability in vivo. Both photoacoustic imaging and NIR-II imaging in vivo confirmed that 1 can effectively accumulate at tumor sites with good signal-to-background ratio and favorable distribution. Guided by precise dual-modal imaging, nano-agent 1 exhibits a superior antitumor performance and less severe side effects compared with a single treatment because of the high efficiency of the chemo-photothermal synergistic therapy. This study shows that nano-agent 1 provides a promising multifunctional theranostic platform for potential applications in biomedicine.
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