Journal
PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES
Volume 95, Issue 7, Pages 358-377Publisher
JAPAN ACAD
DOI: 10.2183/pjab.95.026
Keywords
axon guidance; proteomics; phosphorylation; superresolution microscopy; lipid rafts; chondroitin sulfate
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Funding
- KAKENHI from the MEXT
- KAKENHI from JSPS
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The neuronal growth cone is a highly motile, specialized structure for extending neuronal processes. This structure is essential for nerve growth, axon pathfinding, and accurate synaptogenesis. Growth cones are important not only during development but also for plasticity-dependent synaptogenesis and neuronal circuit rearrangement following neural injury in the mature brain. However, the molecular details of mammalian growth cone function are poorly understood. This review examines molecular findings on the function of the growth cone as a result of the introduction of novel methods such superresolution microscopy and (phospho)proteomics. These results increase the scope of our understating of the molecular mechanisms of growth cone behavior in the mammalian brain.
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