Journal
PRENATAL DIAGNOSIS
Volume 40, Issue 1, Pages 28-37Publisher
WILEY
DOI: 10.1002/pd.5562
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Funding
- Medical Research Council [MR/R00218/1, MR/R002118/1] Funding Source: Medline
- Department of Health [14/168/02, CDF-2017-10-037, NIHR-CS-012-002, NIHR-CDF-2017-10-037, ICA-CDRF-2017-03-053] Funding Source: Medline
- MRC [MR/R002118/1] Funding Source: UKRI
- National Institutes of Health Research (NIHR) [ICA-CDRF-2017-03-053] Funding Source: National Institutes of Health Research (NIHR)
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A sustained decline in parental consent rates for perinatal autopsies has driven the development of less-invasive methods for death investigation. A wide variety of imaging modalities have been developed for this purpose and include post-mortem whole body magnetic resonance imaging (MRI), ultrasound, computed tomography (CT) and micro-focus CT techniques. These are also vital for minimally invasive methods, which include potential for tissue sampling, such as image guidance for targeted biopsies and laparoscopic-assisted techniques. In this article, we address the range of imaging techniques currently in clinical practice and those under development. Significant advances in high-field MRI and micro-focus CT imaging show particular promise for smaller and earlier gestation foetuses. We also review how MRI biomarkers such as diffusion-weighted imaging and organ volumetric analysis may aid diagnosis and image interpretation in the absence of autopsy data. Three-dimensional printing and augmented reality may help make imaging findings more accessible to parents, colleagues and trainees.
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