Journal
PLOS ONE
Volume 14, Issue 9, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0223339
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Funding
- Canadian Institute for Health Research (CIHR)
- Alberta Ingenuity (Alberta Innovates)
- Swiss National Science Foundation (SNSF) [PBBSP3-146963]
- Snyder Mouse Phenomics Resources Laboratory
- Live Cell Imaging Facility - Snyder Institute for Chronic Diseases at the University of Calgary
- Swiss National Science Foundation (SNF) [PBBSP3_146963] Funding Source: Swiss National Science Foundation (SNF)
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Nanoparticles in polluted air or aerosolized drug nanoparticles predominantly settle in the alveolar lung. Here, we describe a novel, highly effective pathway for the particles to cross the alveolar epithelium and reach the lymph and bloodstream. Amorphous silica nanoparticles, suspended in perfluorocarbon, were instilled into the lungs of mice for intravital microscopy. Particles formed agglomerates that settled on the alveolar wall, half of which were removed from the lung within 30 minutes. TEM histology showed agglomerates in stages of crossing the alveolar epithelium, in large compartments inside the epithelial cells and crossing the basal membrane into the interstitium. This pathway is consistent with published kinetic studies in rats and mice, using a host of (negatively) charged and polar nanoparticles.
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