Related references
Note: Only part of the references are listed.IKs ion-channel pore conductance can result from individual voltage sensor movements
Maartje Westhoff et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)
Investigating the Complex Arrhythmic Phenotype Caused by the Gain-of-Function Mutation KCNQ1-G229D
Xin Zhou et al.
FRONTIERS IN PHYSIOLOGY (2019)
Computational design of membrane proteins using RosettaMembrane
Amanda M. Duran et al.
PROTEIN SCIENCE (2018)
Single channel kinetic analysis of the cAMP effect on IKs mutants, S209F and S27D/S92D
Emely Thompson et al.
CHANNELS (2018)
Flex ddG: Rosetta Ensemble-Based Estimation of Changes in Protein-Protein Binding Affinity upon Mutation
Kyle A. Barlow et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2018)
Mechanisms of KCNQ1 channel dysfunction in long QT syndrome involving voltage sensor domain mutations
Hui Huang et al.
SCIENCE ADVANCES (2018)
New horizons for cystic fibrosis treatment
Isabelle Fajac et al.
PHARMACOLOGY & THERAPEUTICS (2017)
KCNE1 and KCNE3 modulate KCNQ1 channels by affecting different gating transitions
Rene Barro-Soria et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
Competition of calcified calmodulin N lobe and PIP2 to an LQT mutation site in Kv7.1 channel
William Sam Tobelaim et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
Inactivation of KCNQ1 potassium channels reveals dynamic coupling between voltage sensing and pore opening
Panpan Hou et al.
NATURE COMMUNICATIONS (2017)
Ca2+-Calmodulin and PIP2 interactions at the proximal C-terminus of Kv7 channels
William S. Tobelaim et al.
CHANNELS (2017)
Cryo-EM Structure of a KCNQ1/CaM Complex Reveals Insights into Congenital Long QT Syndrome
Ji Sun et al.
CELL (2017)
Protocols for Molecular Modeling with Rosetta3 and RosettaScripts
Brian J. Bender et al.
BIOCHEMISTRY (2016)
Documentation of an Imperative To Improve Methods for Predicting Membrane Protein Stability
Brett M. Kroncke et al.
BIOCHEMISTRY (2016)
Voltage-Dependent Gating: Novel Insights from KCNQ1 Channels
Jianmin Cui
BIOPHYSICAL JOURNAL (2016)
Structure, inhibition and regulation of two-pore channel TPC1 from Arabidopsis thaliana
Alexander F. Kintzer et al.
NATURE (2016)
Structural basis for KCNE3 modulation of potassium recycling in epithelia
Brett M. Kroncke et al.
SCIENCE ADVANCES (2016)
Molecular pathogenesis of long QT syndrome type 2
Jennifer L. Smith et al.
JOURNAL OF ARRHYTHMIA (2016)
Personalized Biochemistry and Biophysics
Brett M. Kroncke et al.
BIOCHEMISTRY (2015)
Microscopic mechanisms for long QT syndrome type 1 revealed by single-channel analysis of IKs with 53 domain mutations in KCNQ1
Jodene Eldstrom et al.
HEART RHYTHM (2015)
KCNQ1 channel modulation by KCNE proteins via the voltage-sensing domain
Koichi Nakajo et al.
JOURNAL OF PHYSIOLOGY-LONDON (2015)
Conformational Stability and Pathogenic Misfolding of the Integral Membrane Protein PMP22
Jonathan P. Schlebach et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2015)
KCNE3 acts by promoting voltage sensor activation in KCNQ1
Rene Barro-Soria et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Migration of PIP2 lipids on voltage-gated potassium channel surface influences channel deactivation
Liping Chen et al.
SCIENTIFIC REPORTS (2015)
PIP2-dependent coupling is prominent in Kv7.1 due to weakened interactions between S4-S5 and S6
Marina A. Kasimova et al.
SCIENTIFIC REPORTS (2015)
An Integrated Framework Advancing Membrane Protein Modeling and Design
Rebecca F. Alford et al.
PLOS COMPUTATIONAL BIOLOGY (2015)
Novel Kv7.1-Phosphatidylinositol 4,5-Bisphosphate Interaction Sites Uncovered by Charge Neutralization Scanning
Karina Eckey et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Lipid14: The Amber Lipid Force Field
Callum J. Dickson et al.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2014)
CHARMM-GUI Membrane Builder Toward Realistic Biological Membrane Simulations
Emilia L. Wu et al.
JOURNAL OF COMPUTATIONAL CHEMISTRY (2014)
Structural mechanism of voltage-dependent gating in an isolated voltage-sensing domain
Qufei Li et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2014)
Combining Structural Modeling with Ensemble Machine Learning to Accurately Predict Protein Fold Stability and Binding Affinity Effects upon Mutation
Niklas Berliner et al.
PLOS ONE (2014)
Structural Basis of a Kv7.1 Potassium Channel Gating Module: Studies of the Intracellular C-Terminal Domain in Complex with Calmodulin
Dana Sachyani et al.
STRUCTURE (2014)
Steric hindrance between S4 and S5 of the KCNQ1/KCNE1 channel hampers pore opening
Koichi Nakajo et al.
NATURE COMMUNICATIONS (2014)
KCNE1 divides the voltage sensor movement in KCNQ1/KCNE1 channels into two steps
Rene Barro-Soria et al.
NATURE COMMUNICATIONS (2014)
Differential Modulations of KCNQ1 by Auxiliary Proteins KCNE1 and KCNE2
Pan Li et al.
SCIENTIFIC REPORTS (2014)
Domain-domain interactions determine the gating, permeation, pharmacology, and subunit modulation of the IKs ion channel
Mark A. Zaydman et al.
ELIFE (2014)
Building KCNQ1/KCNE1 Channel Models and Probing their Interactions by Molecular-Dynamics Simulations
Yu Xu et al.
BIOPHYSICAL JOURNAL (2013)
Control of cystic fibrosis transmembrane conductance regulator membrane trafficking: not just from the endoplasmic reticulum to the Golgi
Carlos M. Farinha et al.
FEBS JOURNAL (2013)
PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data
Daniel R. Roe et al.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2013)
Molecular Mechanisms of Disease-Causing Missense Mutations
Shannon Stefl et al.
JOURNAL OF MOLECULAR BIOLOGY (2013)
Kv7.1 ion channels require a lipid to couple voltage sensing to pore opening
Mark A. Zaydman et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
IKs channels open slowly because KCNE1 accessory subunits slow the movement of S4 voltage sensors in KCNQ1 pore-forming subunits
Katarina J. Ruscic et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Single-channel basis for the slow activation of the repolarizing cardiac potassium current, IKs
Daniel Werry et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
High-Resolution Comparative Modeling with RosettaCM
Yifan Song et al.
STRUCTURE (2013)
An Allosteric Mechanism for Drug Block of the Human Cardiac Potassium Channel KCNQ1
Tao Yang et al.
MOLECULAR PHARMACOLOGY (2013)
Probing the structural basis for differential KCNQ1 modulation by KCNE1 and KCNE2
Yuhong Wang et al.
JOURNAL OF GENERAL PHYSIOLOGY (2012)
Characterization of KCNQ1 atrial fibrillation mutations reveals distinct dependence on KCNE1
Priscilla J. Chan et al.
JOURNAL OF GENERAL PHYSIOLOGY (2012)
OPM database and PPM web server: resources for positioning of proteins in membranes
Mikhail A. Lomize et al.
NUCLEIC ACIDS RESEARCH (2012)
Tracking a complete voltage-sensor cycle with metal-ion bridges
Ulrike Henrion et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Mutation analysis of cases of sudden unexplained death, 15 years after death: Prompt genetic evaluation after resuscitation can save future lives
Aase Wisten et al.
RESUSCITATION (2012)
Mechanism of Voltage Gating in Potassium Channels
Morten O. Jensen et al.
SCIENCE (2012)
How Does KCNE1 Regulate the Kv7.1 Potassium Channel? Model-Structure, Mutations, and Dynamics of the Kv7.1-KCNE1 Complex
Yana Gofman et al.
STRUCTURE (2012)
Allosteric Features of KCNQ1 Gating Revealed by Alanine Scanning Mutagenesis
Li-Juan Ma et al.
BIOPHYSICAL JOURNAL (2011)
Structural Basis of Slow Activation Gating in the Cardiac I-Ks Channel Complex
Nathalie Strutz-Seebohm et al.
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2011)
The S4-S5 Linker of KCNQ1 Channels Forms a Structural Scaffold with the S6 Segment Controlling Gate Closure
Alain J. Labro et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
KCNQ1 Channels Voltage Dependence through a Voltage-dependent Binding of the S4-S5 Linker to the Pore Domain
Frank S. Choveau et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Gating-Related Molecular Motions in the Extracellular Domain of the IKs Channel: Implications for IKs Channelopathy
Yu Hong Wang et al.
JOURNAL OF MEMBRANE BIOLOGY (2011)
Modeling Symmetric Macromolecular Structures in Rosetta3
Frank DiMaio et al.
PLOS ONE (2011)
Generalized Fragment Picking in Rosetta: Design, Protocols and Applications
Dominik Gront et al.
PLOS ONE (2011)
Intermediate states of the Kv1.2 voltage sensor from atomistic molecular dynamics simulations
Lucie Delemotte et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Analysis of the interactions between the C-terminal cytoplasmic domains of KCNQ1 and KCNE1 channel subunits
Renjian Zheng et al.
BIOCHEMICAL JOURNAL (2010)
Long QT syndrome with compound mutations is associated with a more severe phenotype: A Japanese multicenter study
Hideki Itoh et al.
HEART RHYTHM (2010)
State-dependent electrostatic interactions of S4 arginines with E1 in S2 during Kv7.1 activation
Dick Wu et al.
JOURNAL OF GENERAL PHYSIOLOGY (2010)
Solution Structure and Phospholipid Interactions of the Isolated Voltage-Sensor Domain from KvAP
Joel A. Butterwick et al.
JOURNAL OF MOLECULAR BIOLOGY (2010)
Spectrum and prevalence of mutations from the first 2,500 consecutive unrelated patients referred for the FAMILION® long QT syndrome genetic test
Jamie D. Kapplinger et al.
HEART RHYTHM (2009)
The Genetic Basis of Long QT and Short QT Syndromes: A Mutation Update
Paula L. Hedley et al.
HUMAN MUTATION (2009)
Location of KCNE1 relative to KCNQ1 in the IKS potassium channel by disulfide cross-linking of substituted cysteines
David Y. Chung et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
A multiscale model linking ion-channel molecular dynamics and electrostatics to the cardiac action potential
Jonathan R. Silva et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Structure of KCNE1 and implications for how it modulates the KCNQ1 potassium channel
Congbao Kang et al.
BIOCHEMISTRY (2008)
OCTOPUS: improving topology prediction by two-track ANN-based preference scores and an extended topological grammar
Hakan Viklund et al.
BIOINFORMATICS (2008)
KCNQ1 and KCNE1 in the I-Ks channel complex make state-dependent contacts in their extracellular domains
Xulin Xu et al.
JOURNAL OF GENERAL PHYSIOLOGY (2008)
Mechanisms by which atrial fibrillation-associated mutations in the S1 domain of KCNQ1 slow deactivation of IKs channels
Lioara Restier et al.
JOURNAL OF PHYSIOLOGY-LONDON (2008)
Structural models for the KCNQ1 voltage-gated potassium channel
Jarrod A. Smith et al.
BIOCHEMISTRY (2007)
Role of the S6C-terminus in KCNQ1 channel gating
Inge R. Boulet et al.
JOURNAL OF PHYSIOLOGY-LONDON (2007)
Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment
Stephen B. Long et al.
NATURE (2007)
Clustal W and clustal X version 2.0
M. A. Larkin et al.
BIOINFORMATICS (2007)
Toward high-resolution prediction and design of transmembrane helical protein structures
P. Barth et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
KCNE1 and KCNE3 stabilize and/or slow voltage sensing s4 segment of KCNQ1 channel
Koichi Nakajo et al.
JOURNAL OF GENERAL PHYSIOLOGY (2007)
MolProbity: all-atom contacts and structure validation for proteins and nucleic acids
Ian W. Davis et al.
NUCLEIC ACIDS RESEARCH (2007)
The role of S4 charges in voltage-dependent and voltage-independent KCNQ1 potassium channel complexes
Gianina Panaghie et al.
JOURNAL OF GENERAL PHYSIOLOGY (2007)
Phospholipids and the origin of cationic gating charges in voltage sensors
Daniel Schmidt et al.
NATURE (2006)
Automatic atom type and bond type perception in molecular mechanical calculations
Junmei Wang et al.
JOURNAL OF MOLECULAR GRAPHICS & MODELLING (2006)
Spectrum of pathogenic mutations and associated polymorphisms in a cohort of 44 unrelated patients with long QT syndrome
G. Millat et al.
CLINICAL GENETICS (2006)
Voltage sensor conformations in the open and closed states in ROSETTA structural models of K+ channels
Vladimir Yarov-Yarovoy et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Multipass membrane protein structure prediction using Rosetta
V Yarov-Yarovoy et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2006)
Differential roles of S6 domain hinges in the gating of KCNQ potassium channels
G Seebohm et al.
BIOPHYSICAL JOURNAL (2006)
AMBER force-field parameters for phosphorylated amino acids in different protonation states: phosphoserine, phosphothreonine, phosphotyrosine, and phosphohistidine
N Homeyer et al.
JOURNAL OF MOLECULAR MODELING (2006)
The backrub motion: How protein backbone shrugs when a sidechain dances
IW Davis et al.
STRUCTURE (2006)
Genetic testing in the long QT syndrome - Development and validation of an efficient approach to genotyping in clinical practice
C Napolitano et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2005)
Voltage sensor of kv1.2: Structural basis of electromechanical coupling
SB Long et al.
SCIENCE (2005)
Regulation of ion channels by phosphatidylinositol 4,5-bisphosphate
BC Suh et al.
CURRENT OPINION IN NEUROBIOLOGY (2005)
Compendium of cardiac channel mutations in 541 consecutive unrelated patients referred for long QT syndrome genetic testing
DJ Tester et al.
HEART RHYTHM (2005)
Disease-associated mutations cause premature oligomerization of myelin proteolipid protein in the endoplasmic reticulum
E Swanton et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Spectrum and frequency of cardiac channel defects in swimming-triggered arrhythmia syndromes
G Choi et al.
CIRCULATION (2004)
MAMMOTH (Matching molecular models obtained from theory): An automated method for model comparison
AR Ortiz et al.
PROTEIN SCIENCE (2002)
Coupling between voltage sensors and activation gate in voltage-gated K+ channels
Z Lu et al.
JOURNAL OF GENERAL PHYSIOLOGY (2002)
Ion conduction pore is conserved among potassium channels
Z Lu et al.
NATURE (2001)
KCNE2 confers background current characteristics to the cardiac KCNQ1 potassium channel
N Tinel et al.
EMBO JOURNAL (2000)
The voltage sensor in voltage-dependent ion channels
F Bezanilla
PHYSIOLOGICAL REVIEWS (2000)
A constitutively open potassium channel formed by KCNQ1 and KCNE3
BC Schroeder et al.
NATURE (2000)
Hypokalemia-induced long QT syndrome with an underlying novel missense mutation in S4-S5 linker of KCNQ1
T Kubota et al.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY (2000)
Share Paper
