Journal
PLOS ONE
Volume 14, Issue 9, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0222815
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Funding
- Ministry of Science and Technology [MOST 104-2314-B-016-026, MOST 104-2314-B-016-053, MOST 105-2314-B-016-040-MY3]
- Tri-Service General Hospital in Taiwan [TSGH-C104-199, TSGH-C105-005-S03, TSGH-C105-005-S04, TSGH-C105-120, TSGHC105-185, TSGH-C106-006-S01, TSGH-C106-006-S02, TSGH-C106-007-S01, TSGH-C107-005-007-S05, TSGH-C106-161, MAB-105-084]
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Objectives Traits of metabolic syndrome (MetS) and biomarkers of inflammation and endothelial dysfunction were examined. We investigated the differences of various biomarkers among individuals with or without Mets in a gender-specific manner. The gender-specific associations between E-selectin and MetS were further evaluated. Methods A total of 205 patients were recruited from the outpatient clinics of Tri-Service General Hospital, Taipei, Taiwan. Inclusion criteria were age between 20-75 years and BMI < 35 kg/m(2). Demographic, anthropometric and MetS index data were compared between genders. Markers of inflammation and endothelial dysfunction were compared between individuals with or without MetS by gender. Results Age-adjusted E-selectin values showed significant positive correlations with BMI, waist-hip ratio, fasting plasma glucose, systolic and diastolic blood pressure, triglycerides, TNF-alpha, hsCRP and ICAM-1, and inverse correlation with HDL cholesterol. E-selectin levels were positively correlated with numbers of MetS components in females (P < 0.001) but not in males (P = 0.125). Conclusions Increased E-selectin levels are significantly associated with increased MetS risk in females, but not in males.
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