Journal
PHYTOCHEMISTRY LETTERS
Volume 32, Issue -, Pages 56-65Publisher
ELSEVIER
DOI: 10.1016/j.phytol.2019.04.021
Keywords
Acacetin; Flavone; Anti-ageing; Anti-Alzheimer; Atrial fibrillation; Neuroprotective
Categories
Funding
- National Research Foundation, South Africa
- South African Medical Research Council
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Acacetin (5,7-dihydroxy-4-methoxyflavone) is a naturally occurring flavonoid, known to possess numerous pharmacological properties, including neuroprotective, cardioprotective, anticancer, anti-inflammatory, anti-diabetic, and antimicrobial activities. The molecule is widespread throughout the Plant Kingdom, but is particularly abundant in the Asteraceae, Euphorbiaceae, Passifloraceae, Lamiaceae and Malvaceae families. It has been shown to exhibit strong inhibitory effects against glutathione reductase, cyclo-oxygenase, acetylcholinesterase, aldose reductase and xanthine oxidase enzymes. A comprehensive overview of the potential therapeutic applications of acacetin was prepared after collating selected peer-reviewed papers, accessed from online scientific databases, specifically PubMed, Web of Science and Scopus. The mechanism of action, dose forms and structure-activity relationships of the molecule are some of the aspects discussed in the review, to facilitate further research and use of this molecule.
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