Journal
PHYTOCHEMISTRY LETTERS
Volume 32, Issue -, Pages 138-142Publisher
ELSEVIER
DOI: 10.1016/j.phytol.2019.05.017
Keywords
Aspergillus terreus; Laurencia okamurai; Meroterpenoids; Influenza neuraminidase inhibitor; Antibacterial activity
Categories
Funding
- National Natural Science Foundation of China [31330009]
- Natural Science Foundation of Shandong Province [ZR2018BD031]
- China Postdoctoral Science Foundation [2018M632732]
- Taishan Scholar Program from Shandong Province
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Two new meroterpenoids, aperterpenes N (1) and O (2), along with two known structurally related derivatives, terretonins A (3) and G (4), were isolated and identified from the marine algal-derived endophytic fungus Aspergillus terreus EN-539. Their structures and absolute configurations were determined by a detailed interpretation of spectroscopic data and by X-ray crystallographic analysis. This is the first establishment of the absolute configurations for terretonins A (3) and G (4). Compound 1 showed inhibitory activity against influenza neuraminidase (IC50 = 18.0 nM), and compound 4 showed inhibitory activity against Micrococcus luteus and Staphylococcus aureus, with MIC values of 32 and 8 mu g/mL, respectively.
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