Journal
PHYSIOLOGICAL GENOMICS
Volume 51, Issue 9, Pages 432-442Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physiolgenomics.00006.2019
Keywords
cortical region; medial prefrontal cortex; neural circuit; neurological disease; pathophysiology
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Funding
- National Institute of Neurological Disorders and Stroke [R00NS-089824]
- NARSAD Young Investigator Grant
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The medial prefrontal cortex (mPFC) is a crucial cortical region that integrates information from numerous cortical and subcortical areas and converges updated information to output structures. It plays essential roles in the cognitive process. regulation of emotion, motivation, and sociability. Dysfunction of the mPFC has been found in various neurological and psychiatric disorders, such as depression, anxiety disorders, schizophrenia, autism spectrum disorders, Alzheimer's disease, Parkinson's disease, and addiction. In the present review, we summarize the preclinical and clinical studies to illustrate the role of the mPFC in these neurological diseases.
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