Journal
PEDIATRIC NEPHROLOGY
Volume 35, Issue 7, Pages 1203-1209Publisher
SPRINGER
DOI: 10.1007/s00467-019-04288-6
Keywords
Children; Chronic kidney disease; Cardiovascular disease; CKiD; Hypertension; Risk factors; Progression
Categories
Funding
- NIDDK NIH HHS [U24 DK066116, U24 DK082194, U01 DK066174, 5U01DK066143, U01 DK066143] Funding Source: Medline
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Cardiovascular disease (CVD) is common among children and adolescents with chronic kidney disease (CKD) and end-stage kidney disease (ESRD). However, the early accrual of CVD risk factors in children with CKD has not been well studied. The Chronic Kidney Disease in Children (CKiD) Study, a multicenter, prospective cohort study of children with mild-to-moderate CKD at study entry counts among its primary aims investigation of the drivers of CVD risk in this population. As the most prevalent CVD risk factor in children with CKD, blood pressure (BP) has been a major focus of investigation for the CKiD Study Group. Over the first 15 years of the study, landmark publications have better defined the prevalence of hypertension, the frequency with which it is under-recognized and thus undertreated, and the consequences of elevated BP in this cohort. The purpose of this review is to summarize the contributions made by the CKiD Study in advancing knowledge of BP in this high-risk population, and to highlight areas in need of further study.
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