Journal
PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
Volume 36, Issue 10, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ppsc.201900214
Keywords
combined toxicity; toxicity mechanism; zinc oxide nanoparticles
Funding
- National Natural Science Foundation of China [21371115, 11025526, 21671131, 11875185]
- Shanghai University-Universal Medical Imaging Diagnostic Research Foundation [19H00100]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT13078]
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When nanomaterials are exposed to complex systems, such as food, they may cause significant changes in physical and chemical properties and even toxicity. The toxicity evaluation of complex systems is urgent. Unfortunately, so far, there is no database established about the toxicity changes of nanoparticles in composite systems. In this paper, the changes and toxicity mechanism of zinc oxide nanoparticles (ZnO NPs) in a composite system are studied. The results show that the dissolution of zinc ions (Zn2+) in acidic systems (vitamin C, tartaric acid, or citric acid) increases the toxicity of ZnO NPs. However, the toxicity of ZnO NPs is reduced by the complexation effect with Zn2+ in phosphoric acid, phosphate, and glutathione systems. The influence of titanium dioxide nanoparticles (TiO2 NPs) on the toxicity of ZnO NPs depends on size and surface properties. In brief, the intracellular Zn2+ homeostasis level is the decisive factor in determining the toxicity change in complex systems. The results indicate that the toxicity changes are very different in combined systems, which may have potential food safety issues, especially for unstable nanoparticles.
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