Journal
ORGANIC PROCESS RESEARCH & DEVELOPMENT
Volume 23, Issue 8, Pages 1679-1685Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.oprd.9b00194
Keywords
NH-heteroarenes; quaternary ammonium salts; C-N cross-coupling; palladium catalysis; C-N bond cleavage
Categories
Funding
- National Natural Science Foundation of China [21372034]
- State Key Laboratory of Geohazard Prevention and Geoenvironment Protection [SICLGP2018Z002]
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In this paper, we extend the substrate class of Buchwald-Hartwig amination to quaternary ammonium salts. In the presence of Pd(OAc)(2) and t-BuXPhos, the coupling of aryl- or arylmethyltrimethylammonium triflates with NH-heteroarenes via C-N bond cleavage affords the desired N-aryl or N-arylmethyl heteroarenes in moderate to excellent yields.
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