Journal
ORGANIC LETTERS
Volume 21, Issue 16, Pages 6289-6294Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b02171
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Funding
- Hong Kong Research Grants Council [PolyU 153006/15P]
- State Key Laboratory of Chemical Biology and Drug Discovery
- Department of Applied Biology and Chemical Technology
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Asymmetric catalysis by using novel chiral O,O'-chelated 4,4'-biphenol cyclometalated oxazoline gold(III) complexes has been developed. A high yield (<= 89%) and a high enantioselectivity (<= 90% ee) were achieved in asymmetric carboalkoxylation of alkynes. Enantioselectivity could be significantly improved from 19% to 90% ee by increasing the steric size of the substituent on the chiral oxazoline ligand. Catalytically active Au-III species and the origin of chiral induction are proposed.
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