Journal
ORGANIC LETTERS
Volume 21, Issue 16, Pages 6329-6332Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b02226
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Funding
- China Scholarship Council (CSC)
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Herein a synergistic combination of a nickel catalyst and benzaldehyde for the utilization of amides and thioethers in C(sp(3))-H alkylation and arylation reactions employing simple aryl or alkyl halides is reported. This method provides a simple and cheap strategy for the direct functionalization of amides and thioethers. Readily available starting materials, mild reaction conditions, a good functionalgroup tolerance, and a broad substrate scope make this methodology attractive and practical for pharmaceutical and synthetic chemistry.
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