Journal
ORGANIC LETTERS
Volume 21, Issue 17, Pages 7060-7064Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b02626
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Funding
- National Natural Science Foundation of China [21672109, 21871148, 21472097]
- Natural Science Foundation of Tianjin [15JCYBJC20000]
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Phosphine-catalyzed divergent [4+3] domino annulations of fluorinated imidoyl chlorides with MBH carbonates were developed. Two classes of perfluoroalkylated benzazepines were obtained in moderate to good yields via an interesting dearomatization/rearomatization sequence. Remarkably, the fluorinated imidoyl chlorides could be utilized for the first time as a new four-atom building block in phosphine catalysis. Moreover, the proposed mechanism is supported by capturing the intermediate.
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