Journal
ORGANIC LETTERS
Volume 21, Issue 19, Pages 7804-7808Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b02779
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The direct reduction of carboxylic acids to aldehydes is a fundamental transformation in organic synthesis. The combination of an air-stable Ni precatalyst, dimethyl dicarbonate as an activator, and silane reductant effects this reduction for a wide variety of substrates, including pharmaceutically relevant structures, in good yields and with no overreduction to alcohols. Moreover, this methodology is scalable, allows access to deuterated aldehydes, and is also compatible with one-pot utilization of the aldehyde products.
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