Journal
ORGANIC LETTERS
Volume 21, Issue 18, Pages 7582-7586Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b02861
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Funding
- Japan Society for the Promotion of Science (JSPS) [16H06449, 19H02898, 19K22291, 17K15265]
- Takeda Science Foundation
- Institution of Fermentation at Osaka
- Japan Antibiotics Research Association
- Uehara Memorial Foundation
- HOKUTO Biochemical Research Foundation
- Grants-in-Aid for Scientific Research [19K22291, 19H02898, 17K15265] Funding Source: KAKEN
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LaeA is a positive global regulator of secondary metabolism in Ascomycetes, but its role in Basidiomycetes, including medicinal mushrooms, remains uncharacterized. Here, knockout of laeA in the model mushroom Coprinopsis cinerea unexpectedly upregulated the biosynthesis of a novel siderophore, coprinoferrin. Furthermore, knockout of the nonribosomal peptide synthetase-encoding cpf1 responsible for coprinoferrin biosynthesis resulted in growth defect and loss of fruiting body formation, indicating the complex role that this natural product plays in fungal cell development.
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