Journal
ORGANIC LETTERS
Volume 21, Issue 18, Pages 7514-7518Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b02793
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Funding
- DAE-BRNS, India (Young Scientist Research Award) [37(2)/20/33/2016-BRNS]
- IIT Roorkee [SMILE-32]
- SERB-NPDF [PDF/2017/002784]
- [DST/2018/1F180079]
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An efficient Fe-catalyzed system is reported for direct alpha-olefination of methyl-substituted N-heteroarenes with primary alcohols. The catalytic dehydrogenative coupling enables a series of functionalized E-olefinated N-heteroaromatics with excellent selectivity (>99%). Initial mechanistic studies including deuterium-labeling experiments provide evidence for the participation of the benzylic C-H/D bond of alcohols.
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