Journal
ORGANIC LETTERS
Volume 21, Issue 19, Pages 7702-7707Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b02433
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Funding
- National Natural Science Foundation of China [21602142]
- Fundamental Research Funds for the Central Universities
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Reported herein is an effective strategy for oxidative cross-coupling of indoles with various aldehydes. The strategy is based on a two-step transformation via a well-known Mannich-type reaction and a C-N bond cleavage for carbonyl introduction. The key step-the C-N bond cleavage of the Mannich product-was enabled by electrochemistry. This strategy (with over 40 examples) ensures excellent functional-group tolerance as well as late-stage functionalization of pharmaceutical molecules.
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