Journal
ORGANIC LETTERS
Volume 21, Issue 17, Pages 6643-6647Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b02183
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Funding
- National Key R&D Program of China [2017YFA0208100, 2016YFA0602900]
- National Natural Science Foundation of China [91853124, 21778057, 21420102003]
- Chinese Academy of Sciences
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An efficient iodide-catalyzed/hydrogen peroxide mediated sulfenylation and selenylation of unprotected uracil and its derivatives with simple thiols and diselenides was established. This coupling tolerates a broad variety of functional groups to provide diverse 5-sulfur/selenium-substituted uracil derivatives in good to excellent yields (up to 93%).
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