Journal
NUTRITION RESEARCH REVIEWS
Volume 33, Issue 1, Pages 43-49Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0954422419000180
Keywords
Ruminants; Copper transport; Liver metabolism; Thiomolybdate
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Funding
- University of Nottingham, School of Veterinary Science and Medicine
- Trouw Nutrition RD
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Ruminants are recognised to suffer from Cu-responsive disorders. Present understanding of Cu transport and metabolism is limited and inconsistent across vets and veterinary professionals. There has been much progress from the studies of the 1980s and early 1990s in cellular Cu transport and liver metabolism which has not been translated into agricultural practice. Cu metabolism operates in regulated pathways of Cu trafficking rather than in pools of Cu lability. Cu in the cell is chaperoned to enzyme production, retention within metallothionein or excretion via the Golgi into the blood. The hepatocyte differs in that Cu-containing caeruloplasmin can be synthesised to provide systemic Cu supply and excess Cu is excreted via bile. The aim of the present review is to improve understanding and highlight the relevant progress in relation to ruminants through the translation of newer findings from medicine and non-ruminant animal models into ruminants.
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