Journal
NEUROREPORT
Volume 30, Issue 11, Pages 753-759Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNR.0000000000001192
Keywords
delta subunit-containing GABAA receptor; adult; anxiety; gender; puberty
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Funding
- National Natural Science Foundation of China [81601179, 81760505, 81771459]
- Scientific Project of Jiangxi Province [20171BAB214022, GJJ150175, 20171BAB215039, GJJ150195, 20172BCB22005]
- National Undergraduates' Innovation and Entrepreneurship Training Program [201701070]
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The delta subunit-containing GABA(A) receptor [GABA(A)(delta)R], which is exclusively situated in the extrasynaptic space, has considerable influence on emotion and behavior. Although the expression of this receptor experiences dramatic fluctuation during postnatal development, it remains unknown whether it regulates emotion in a development-dependent manner. Here, by using mice with genetic deletion of GABA(A)(delta)R (knockout) and their wild-type littermates, we examined the role of GABA(A)(delta) R in regulating anxiety-like behavior, as measured with open field test( OFT) and elevated plus maze during the transition from puberty to adulthood. We observed that for female mice, the knockout ones at puberty but not adulthood showed increased anxiety-like behavior in the OFT relative to their wild-type littermates. However, such increase was not observed in elevated plus maze. For male mice, no between-genotype differences were observed in both tests at the above two developmental stages. Our results suggest that GABA(A)(delta)R preferentially affects the anxiety-like behavior in OFT in a development-dependent manner, but only in female mice. Copyright (C) 2019 Wolters Kluwer Health, Inc. All rights reserved.
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