Journal
AUTOPHAGY
Volume 13, Issue 2, Pages 223-224Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15548627.2016.1267075
Keywords
autophagy; bacteria; cancer; host; xenophagy
Categories
Funding
- Damon Runyon postdoctoral fellowship [DRG-2213-15]
- NIH [GM053396]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM053396] Funding Source: NIH RePORTER
Ask authors/readers for more resources
In eukaryotes, xenophagy is defined as a type of selective macroautophagy/autophagy that is used for eliminating invading pathogens. In contrast to other types of selective autophagy, such as mitophagy, pexophagy and ribophagy, xenophagy is used by eukaryotes for targeting microbeshence the prefix xeno meaning other or foreignthat have infected a host cell, leading to their lysosomal degradation. This unique characteristic links xenophagy to antibacterial and antiviral defenses, as well as the immune response. Furthermore, recent studies suggest a complicated role of xenophagy in cancer, through either suppressing tumorigenesis or promoting survival of established tumors. In this issue, Sui etal. summarize previous and current studies of xenophagy and consider them in the context of anticancer treatment.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available