Journal
NEUROBIOLOGY OF AGING
Volume 80, Issue -, Pages 99-110Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2019.04.007
Keywords
Inferior colliculus; GABA(A) receptor; GABA(A)R gamma(1) subunit; GABAergic; Glutamatergic; Age-related hearing loss
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Funding
- National Institute on Aging, United States rodent colony
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Age-related hearing loss may result, in part, from declining levels of gamma-amino butyric acid (GABA) in the aging inferior colliculus (IC). An upregulation of the GABA(A)R gamma(1) subunit, which has been shown to increase sensitivity to GABA, occurs in the aging IC. We sought to determine whether the upregulation of the GABA(A)R gamma(1) subunit was specific to GABAergic or glutamatergic IC cells. We used immunohistochemistry for glutamic acid decarboxylase and the GABA(A)R gamma(1) subunit at 4 age groups in the IC of Fisher Brown Norway rats. The percentage of somas that expressed the gamma(1) subunit and the number of subunits on each soma were quantified. Our results show that GABAergic and glutamatergic IC cells increasingly expressed the gamma(1) subunit from young age until expression peaked during middle age. At old age (similar to 77% of life span), the number of GABA(A)R gamma(1) subunits per cell sharply decreased for both cell types. These results, along with previous studies, suggest inhibitory and excitatory IC circuits may express the GABA(A)R gamma(1) subunit in response to the age-related decline of available GABA. Published by Elsevier Inc.
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