Journal
AUTOPHAGY
Volume 12, Issue 5, Pages 898-899Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15548627.2015.1121361
Keywords
Cellular senescence; DNA damage response (DDR); GATA4; selective autophagy; senescence-associated secretory phenotype (SASP); SQSTM1/p62
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Funding
- Howard Hughes Medical Institute Funding Source: Medline
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Autophagy and cellular senescence are stress responses essential for homeostasis. While recent studies indicate a genetic relationship between autophagy and senescence, whether autophagy acts positively or negatively on senescence is still subject to debate. Although autophagy was originally recognized as a nonspecific lysosomal degradation pathway (general autophagy), increasing evidence supports a selective form of autophagy that mediates the degradation of specific targets (selective autophagy). Our recent study revealed distinctive roles of selective autophagy and general autophagy in the regulation of senescence, at least in part resolving apparently contradictory reports regarding the relationship between these 2 important homeostatic stress responses.
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