Journal
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 26, Issue 9, Pages 783-791Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41594-019-0287-x
Keywords
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Funding
- National Institutes of Health
- American Cancer Society
- Leukemia and Lymphoma Society
- Rockefeller University
- Starr Cancer Consortuim
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The landmark 1969 discovery of nuclear RNA polymerases I, II and III in diverse eukaryotes represented a major turning point in the field that, with subsequent elucidation of the distinct structures and functions of these enzymes, catalyzed an avalanche of further studies. In this Review, written from a personal and historical perspective, I highlight foundational biochemical studies that led to the discovery of an expanding universe of the components of the transcriptional and regulatory machineries, and a parallel complexity in gene-specific mechanisms that continue to be explored to the present day.
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