Journal
NATURE REVIEWS ENDOCRINOLOGY
Volume 15, Issue 11, Pages 651-665Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41574-019-0246-y
Keywords
-
Categories
Funding
- National Institute of Diabetes and Digestive and Kidney Diseases [DK099134]
- Biomedical Laboratory Research and Development Service of the Veterans Affairs Office of Research and Development [BX003724, BX001234]
- Senior Research Career Scientist Award from the Department of Veterans Affairs
Ask authors/readers for more resources
Osteoblasts are specialized mesenchymal cells that synthesize bone matrix and coordinate the mineralization of the skeleton. These cells work in harmonywith osteoclasts, which resorb bone, in a continuous cycle that occurs throughout life. The unique function of osteoblasts requires substantial amounts of energy production, particularly during states of new bone formation and remodelling. Over the last 15 years, studies have shown that osteoblasts secrete endocrine factors that integrate the metabolic requirements of bone formation with global energy balance through the regulation of insulin production, feeding behaviour and adipose tissue metabolism. In this article, we summarize the current understanding of three osteoblast-derived metabolic hormones (osteocalcin, lipocalin and sclerostin) and the clinical evidence that suggests the relevance of these pathways in humans, while also discussing the necessity of specific energy substrates (glucose, fatty acids and amino acids) to fuel bone formation and promote osteoblast differentiation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available