Related references
Note: Only part of the references are listed.Innate Immune Signaling Organelles Display Natural and Programmable Signaling Flexibility
Yunhao Tan et al.
CELL (2019)
Acetylation Blocks cGAS Activity and Inhibits Self-DNA-Induced Autoimmunity
Jiang Dai et al.
CELL (2019)
Toll-like receptor 9-dependent interferon production prevents group 2 innate lymphoid cell-driven airway hyperreactivity
Christina Li -Ping Thio et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)
Drug developers switch gears to inhibit STING
Cormac Sheridan
NATURE BIOTECHNOLOGY (2019)
OAS-RNase L innate immune pathway mediates the cytotoxicity of a DNA-demethylating drug
Shuvojit Banerjee et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)
cGAS in action: Expanding roles in immunity and inflammation
Andrea Ablasser et al.
SCIENCE (2019)
RNA-based adjuvant CV8102 enhances the immunogenicity of a licensed rabies vaccine in a first-in-human trial
Fatma Doener et al.
VACCINE (2019)
The STING agonist 5,6-dimethylxanthenone-4-acetic acid (DMXAA) stimulates an antiviral state and protects mice against herpes simplex virus-induced neurological disease
Stacey Ceron et al.
VIROLOGY (2019)
STING-mediated intestinal barrier dysfunction contributes to lethal sepsis
Qiongyuan Hu et al.
EBIOMEDICINE (2019)
Effects of 24-week Toll-like receptor 9 agonist treatment in HIV type 1+individuals
Line K. Vibholm et al.
AIDS (2019)
Pediatric Evans syndrome is associated with a high frequency of potentially damaging variants in immune genes
Jerome Hadjadj et al.
BLOOD (2019)
RGS1 silencing inhibits the inflammatory response and angiogenesis in rheumatoid arthritis rats through the inactivation of Toll-like receptor signaling pathway
Xumin Hu et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2019)
Systemic clinical tumor regressions and potentiation of PD1 blockade with in situ vaccination
Linda Hammerich et al.
NATURE MEDICINE (2019)
Spotlight on anifrolumab and its potential for the treatment of moderate-to-severe systemic lupus erythematosus: evidence to date
Renaud Felten et al.
DRUG DESIGN DEVELOPMENT AND THERAPY (2019)
STING agonists activate latently infected cells and enhance SIV-specific responses ex vivo in naturally SIV controlled cynomolgus macaques
Takuya Yamamoto et al.
SCIENTIFIC REPORTS (2019)
Immunotherapeutic effects of intratumoral nanoplexed poly I:C
M. Angela Aznar et al.
JOURNAL FOR IMMUNOTHERAPY OF CANCER (2019)
Severe influenza pneumonitis in children with inherited TLR3 deficiency
Hye Kyung Lim et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2019)
Mitochondrial DNA: A new driver for sex differences in spontaneous hypertension
Cinthya Echem et al.
PHARMACOLOGICAL RESEARCH (2019)
Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression
Lodoe Lama et al.
NATURE COMMUNICATIONS (2019)
Poly-ICLC, a TLR3 Agonist, Induces Transient Innate Immune Responses in Patients With Treated HIV-Infection: A Randomized Double-Blinded Placebo Controlled Trial
Mansi Saxena et al.
FRONTIERS IN IMMUNOLOGY (2019)
STING-mediated inflammation in Kupffer cells contributes to progression of nonalcoholic steatohepatitis
Yongsheng Yu et al.
JOURNAL OF CLINICAL INVESTIGATION (2019)
Loss of ADAR1 in tumours overcomes resistance to immune checkpoint blockade
Jeffrey J. Ishizuka et al.
NATURE (2019)
The TLR9 agonist MGN1703 triggers a potent type I interferon response in the sigmoid colon
A. R. krarup et al.
MUCOSAL IMMUNOLOGY (2018)
cGAS drives noncanonical-inflammasome activation in age-related macular degeneration
Nagaraj Kerur et al.
NATURE MEDICINE (2018)
Combined immunotherapy encompassing intratumoral poly-ICLC, dendritic-cell vaccination and radiotherapy in advanced cancer patients
M. E. Rodriguez-Ruiz et al.
ANNALS OF ONCOLOGY (2018)
Splicing variant of WDFY4 augments MDA5 signalling and the risk of clinically amyopathic dermatomyositis
Yuta Kochi et al.
ANNALS OF THE RHEUMATIC DISEASES (2018)
RIG-I and Other RNA Sensors in Antiviral Immunity
Kwan T. Chow et al.
ANNUAL REVIEW OF IMMUNOLOGY, VOL 36 (2018)
Effective cancer immunotherapy in mice by polyIC-imiquimod complexes and engineered magnetic nanoparticles
Ana Isabel Bocanegra Gondan et al.
BIOMATERIALS (2018)
Recurrence of vulval intraepithelial neoplasia following treatment with cidofovir or imiquimod: results from a multicentre, randomised, phase II trial (RT3VIN)
C. N. Hurt et al.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY (2018)
Cytosolic DNA Sensing in Organismal Tumor Control
Claire Vanpouille-Box et al.
CANCER CELL (2018)
SnapShot: cGAS-STING Signaling
Lorenzo Galluzzi et al.
CELL (2018)
Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown
Hachung Chung et al.
CELL (2018)
Activation of Stimulator of Interferon Genes (STING) and Sjogren Syndrome
J. Papinska et al.
JOURNAL OF DENTAL RESEARCH (2018)
Polyglutamine binding protein 1 (PQBP1) inhibits innate immune responses to cytosolic DNA
Jessica L. Shannon et al.
MOLECULAR IMMUNOLOGY (2018)
Immunological Mechanisms Responsible for Radiation-Induced Abscopal Effect
Maria E. Rodriguez-Ruiz et al.
TRENDS IN IMMUNOLOGY (2018)
TLR9 activation via microglial glucocorticoid receptors contributes to degeneration of midbrain dopamine neurons
Layal Maatouk et al.
NATURE COMMUNICATIONS (2018)
Warming Cold Melanoma with TLR9 Agonists
Alissa Poh
CANCER DISCOVERY (2018)
Inhibition of Cyclic GMP-AMP Synthase Using a Novel Antimalarial Drug Derivative in Trex1-Deficient Mice
Jie An et al.
ARTHRITIS & RHEUMATOLOGY (2018)
Anti-Melanoma immunity and local regression of cutaneous metastases in melanoma patients treated with monobenzone and imiquimod; a phase 2 a trial
Hansje-Eva Teulings et al.
ONCOIMMUNOLOGY (2018)
A minimal RNA ligand for potent RIG-I activation in living mice
Melissa M. Linehan et al.
SCIENCE ADVANCES (2018)
Mitochondrial double-stranded RNA triggers antiviral signalling in humans
Ashish Dhir et al.
NATURE (2018)
Targeting STING with covalent small-molecule inhibitors
Simone M. Haag et al.
NATURE (2018)
The hallmarks of successful anticancer immunotherapy
Lorenzo Galluzzi et al.
SCIENCE TRANSLATIONAL MEDICINE (2018)
In Situ Vaccination with a TLR9 Agonist and Local Low-Dose Radiation Induces Systemic Responses in Untreated Indolent Lymphoma
Matthew J. Frank et al.
CANCER DISCOVERY (2018)
SD-101 in Combination with Pembrolizumab in Advanced Melanoma: Results of a Phase Ib, Multicenter Study
Antoni Ribas et al.
CANCER DISCOVERY (2018)
ADAR1-mediated RNA editing is required for thymic self-tolerance and inhibition of autoimmunity
Taisuke Nakahama et al.
EMBO REPORTS (2018)
Expression of STING Is Increased in Liver Tissues From Patients With NAFLD and Promotes Macrophage-Mediated Hepatic Inflammation and Fibrosis in Mice
Xianjun Luo et al.
GASTROENTEROLOGY (2018)
Systematic Screening of Commonly Used Commercial Transfection Reagents towards Efficient Transfection of Single-Stranded Oligonucleotides
Tao Wang et al.
MOLECULES (2018)
Design of amidobenzimidazole STING receptor agonists with systemic activity
Joshi M. Ramanjulu et al.
NATURE (2018)
Linking cellular stress responses to systemic homeostasis
Lorenzo Galluzzi et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)
WDFY4 is required for cross-presentation in response to viral and tumor antigens
Derek J. Theisen et al.
SCIENCE (2018)
Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells
Hugh S. Gannon et al.
NATURE COMMUNICATIONS (2018)
Magnitude of Therapeutic STING Activation Determines CD8+ T Cell-Mediated Anti-tumor Immunity
Kelsey E. Sivick et al.
CELL REPORTS (2018)
The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING
Senlin Li et al.
CELL REPORTS (2018)
Trial Watch: Toll-like receptor agonists in cancer immunotherapy
Melody Smith et al.
ONCOIMMUNOLOGY (2018)
Successful Treatment of Nivolumab-Resistant Multiple In-Transit Melanomas with Ipilimumab and Topical Imiquimod
Taku Fujimura et al.
CASE REPORTS IN ONCOLOGY (2018)
Innate Immunity Stimulation via Toll-Like Receptor 9 Ameliorates Vascular Amyloid Pathology in Tg-SwDI Mice with Associated Cognitive Benefits
Henrieta Scholtzova et al.
JOURNAL OF NEUROSCIENCE (2017)
Induction of humoral and cellular immune response to hepatitis B virus (HBV) vaccine can be upregulated by CpG oligonucleotides complexed with Dectin-1 ligand
H. Ito et al.
JOURNAL OF VIRAL HEPATITIS (2017)
Absence of RNase H2 triggers generation of immunogenic micronuclei removed by autophagy
Kareen Bartsch et al.
HUMAN MOLECULAR GENETICS (2017)
Recurrent rhinovirus infections in a child with inherited MDA5 deficiency
Ian T. Lamborn et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2017)
Vaccination with poly (IC: LC) and peptide-pulsed autologous dendritic cells in patients with pancreatic cancer
Shikhar Mehrotra et al.
JOURNAL OF HEMATOLOGY & ONCOLOGY (2017)
Cutting Edge: Activation of STING in T Cells Induces Type I IFN Responses and Cell Death
Bridget Larkin et al.
JOURNAL OF IMMUNOLOGY (2017)
SB 9200, a novel agonist of innate immunity, shows potent antiviral activity against resistant HCV variants
Meleri Jones et al.
JOURNAL OF MEDICAL VIROLOGY (2017)
HIV-1-Associated Atherosclerosis Unraveling the Missing Link
Alison Kearns et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2017)
5'-Triphosphate siRNA targeting MDR1 reverses multi-drug resistance and activates RIG-I-induced immune-stimulatory and apoptotic effects against human myeloid leukaemia cells
Dengzhe Li et al.
LEUKEMIA RESEARCH (2017)
IRF3 and type I interferons fuel a fatal response to myocardial infarction
Kevin R. King et al.
NATURE MEDICINE (2017)
Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles
Lorenzo Galluzzi et al.
NATURE REVIEWS DRUG DISCOVERY (2017)
Beyond TNF: TNF superfamily cytokines as targets for the treatment of rheumatic diseases
Michael Croft et al.
NATURE REVIEWS RHEUMATOLOGY (2017)
Antiviral Efficacy and Host Immune Response Induction during Sequential Treatment with SB 9200 Followed by Entecavir in Woodchucks
Manasa Suresh et al.
PLOS ONE (2017)
CRISPR-Cas: Adapting to change
Simon A. Jackson et al.
SCIENCE (2017)
Human innate responses and adjuvant activity of TLR ligands in vivo in mice reconstituted with a human immune system
Liang Cheng et al.
VACCINE (2017)
A small-molecule IRF3 agonist functions as an influenza vaccine adjuvant by modulating the antiviral immune response
Peter Probst et al.
VACCINE (2017)
Signalling strength determines proapoptotic functions of STING
Muhammet F. Gulen et al.
NATURE COMMUNICATIONS (2017)
IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes
Jessica F. Almine et al.
NATURE COMMUNICATIONS (2017)
DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity
Claire Vanpouille-Box et al.
NATURE COMMUNICATIONS (2017)
Hepatitis C virus and atherosclerosis: A legacy after virologic cure?
M. F. Bassendine et al.
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY (2017)
NAB2 is a novel immune stimulator of MDA-5 that promotes a strong type I interferon response
Anne Oberson et al.
Oncotarget (2017)
A TLR3-Specific Adjuvant Relieves Innate Resistance to PD-L1 Blockade without Cytokine Toxicity in Tumor Vaccine Immunotherapy
Yohei Takeda et al.
CELL REPORTS (2017)
Intratumoral STING Activation with T-cell Checkpoint Modulation Generates Systemic Antitumor Immunity
Casey R. Ager et al.
CANCER IMMUNOLOGY RESEARCH (2017)
Natural Modulators of Endosomal Toll-Like Receptor-Mediated Psoriatic Skin Inflammation
Chao-Yang Lai et al.
JOURNAL OF IMMUNOLOGY RESEARCH (2017)
The STING agonist DMXAA triggers a cooperation between T lymphocytes and myeloid cells that leads to tumor regression
Julia M. Weiss et al.
ONCOIMMUNOLOGY (2017)
Topical Imiquimod Plus Nab-paclitaxel for Breast Cancer Cutaneous Metastases A Phase 2 Clinical Trial
Lupe G. Salazar et al.
JAMA ONCOLOGY (2017)
A pilot study of the immunogenicity of a 9-peptide breast cancer vaccine plus poly-ICLC in early stage breast cancer
Patrick M. Dillon et al.
JOURNAL FOR IMMUNOTHERAPY OF CANCER (2017)
Targeting immunosuppressive adenosine in cancer
D. Vijayan et al.
NATURE REVIEWS CANCER (2017)
Local Adjuvant Treatment with Low-Dose CpG-B Offers Durable Protection against Disease Recurrence in Clinical Stage I-II Melanoma: Data from Two Randomized Phase II Trials
Bas D. Koster et al.
CLINICAL CANCER RESEARCH (2017)
Safety and pharmacodynamics of intranasal GSK2245035, a TLR7 agonist for allergic rhinitis: A randomized trial
A. K. Ellis et al.
CLINICAL AND EXPERIMENTAL ALLERGY (2017)
Multi-receptor detection of individual bacterial products by the innate immune system
Karen J. Kieser et al.
NATURE REVIEWS IMMUNOLOGY (2017)
IMO-8400, a toll-like receptor 7, 8, and 9 antagonist, demonstrates clinical activity in a phase 2a, randomized, placebo-controlled trial in patients with moderate-to-severe plaque psoriasis
Deepak M. W. Balak et al.
CLINICAL IMMUNOLOGY (2017)
Systemic autoimmunity induced by the TLR7/8 agonist Resiquimod causes myocarditis and dilated cardiomyopathy in a new mouse model of autoimmune heart disease
Muneer G. Hasham et al.
DISEASE MODELS & MECHANISMS (2017)
Immunogenic cell death in cancer and infectious disease
Lorenzo Galluzzi et al.
NATURE REVIEWS IMMUNOLOGY (2017)
Oligodeoxynucleotide inhibition of Toll-like receptors 3, 7, 8, and 9 suppresses cytokine production in a human rheumatoid arthritis model
Sandra Sacre et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2016)
Agonist-Mediated Activation of STING Induces Apoptosis in Malignant B Cells
Chih-Hang Anthony Tang et al.
CANCER RESEARCH (2016)
Recognition of Endogenous Nucleic Acids by the Innate Immune System
Axel Roers et al.
IMMUNITY (2016)
Strategies for designing synthetic immune agonists
Tom Y. -H. Wu
IMMUNOLOGY (2016)
Imiquimod in dermatology: an overview
Edith Hanna et al.
INTERNATIONAL JOURNAL OF DERMATOLOGY (2016)
Dyschromatosis Symmetrica Hereditaria and Aicardi-Goutieres Syndrome 6 Are Phenotypic Variants Caused by ADAR1 Mutations
Michihiro Kono et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2016)
Viral evasion of intracellular DNA and RNA sensing
Ying Kai Chan et al.
NATURE REVIEWS MICROBIOLOGY (2016)
Functional polymorphisms of the TLR7 and TLR8 genes contribute to Mycobacterium tuberculosis infection
Yung-Fa Lai et al.
TUBERCULOSIS (2016)
Cancer therapies activate RIG-I-like receptor pathway through endogenous non-coding RNAs
Diana Rose E. Ranoa et al.
ONCOTARGET (2016)
STING Pathway Activation Stimulates Potent Immunity against Acute Myeloid Leukemia
Emily Curran et al.
CELL REPORTS (2016)
Which therapeutic strategy will achieve a cure for HIV-1?
Anthony R. Cillo et al.
CURRENT OPINION IN VIROLOGY (2016)
Antiviral Efficacy and Host Innate Immunity Associated with SB 9200 Treatment in the Woodchuck Model of Chronic Hepatitis B
Kyle E. Korolowicz et al.
PLOS ONE (2016)
Self-regulation and cross-regulation of pattern-recognition receptor signalling in health and disease
Xuetao Cao
NATURE REVIEWS IMMUNOLOGY (2016)
Discriminating self from non-self in nucleic acid sensing
Martin Schlee et al.
NATURE REVIEWS IMMUNOLOGY (2016)
Topical resiquimod can induce disease regression and enhance T-cell effector functions in cutaneous T-cell lymphoma
Alain H. Rook et al.
BLOOD (2015)
Early Clinical Evaluation of the Intranasal TLR7 Agonist GSK2245035: Use of Translational Biomarkers to Guide Dosing and Confirm Target Engagement
D. Tsitoura et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2015)
Sex hormone affects the severity of non-alcoholic steatohepatitis through the MyD88-dependent IL-6 signaling pathway
Guangda Xin et al.
EXPERIMENTAL BIOLOGY AND MEDICINE (2015)
Isoforms of RNA-Editing Enzyme ADAR1 Independently Control Nucleic Acid Sensor MDA5-Driven Autoimmunity and Multi-organ Development
Kathleen Pestal et al.
IMMUNITY (2015)
Sequential Activation of Two Pathogen-Sensing Pathways Required for Type I Interferon Expression and Resistance to an Acute DNA Virus Infection
Ren-Huan Xu et al.
IMMUNITY (2015)
Inhibition of indoleamine 2,3-dioxygenase activity enhances the anti-tumour effects of a Toll-like receptor 7 agonist in an established cancer model
Hiroyasu Ito et al.
IMMUNOLOGY (2015)
Toll-like receptor 8 deletion accelerates autoimmunity in a mouse model of lupus through a Toll-like receptor 7-dependent mechanism
Ngoc Lan Tran et al.
IMMUNOLOGY (2015)
Cutting Edge: Inhibiting TBK1 by Compound II Ameliorates Autoimmune Disease in Mice
Maroof Hasan et al.
JOURNAL OF IMMUNOLOGY (2015)
RIG-I contributes to the innate immune response after cerebral ischemia
Frank J. Brand et al.
JOURNAL OF INFLAMMATION-LONDON (2015)
RNA EDITING RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself
Brian J. Liddicoat et al.
SCIENCE (2015)
Hepatitis B surface antigen (HBsAg) and core antigen (HBcAg) combine CpG oligodeoxynucletides as a novel therapeutic vaccine for chronic hepatitis B infection
Jianqiang Li et al.
VACCINE (2015)
Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity
Leticia Corrales et al.
CELL REPORTS (2015)
BRCA1 Regulates IFI16 Mediated Nuclear Innate Sensing of Herpes Viral DNA and Subsequent Induction of the Innate Inflammasome and Interferon-β Responses
Dipanjan Dutta et al.
PLOS PATHOGENS (2015)
Promotion of Inflammatory Arthritis by Interferon Regulatory Factor 5 in a Mouse Model
Pierre Duffau et al.
ARTHRITIS & RHEUMATOLOGY (2015)
Resiquimod as an Immunologic Adjuvant for NY-ESO-1 Protein Vaccination in Patients with High-Risk Melanoma
Rachel Lubong Sabado et al.
CANCER IMMUNOLOGY RESEARCH (2015)
STING Agonists Induce an Innate Antiviral Immune Response against Hepatitis B Virus
Fang Guo et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2015)
Using Poly I:C as an adjuvant does not induce or exacerbate models of systemic lupus erythematosus
Tami Annable et al.
AUTOIMMUNITY (2015)
Induction of Robust Type-I CD8+ T-cell Responses in WHO Grade 2 Low-Grade Glioma Patients Receiving Peptide-Based Vaccines in Combination with Poly-ICLC
Hideho Okada et al.
CLINICAL CANCER RESEARCH (2015)
Translating nucleic acid-sensing pathways into therapies
Tobias Junt et al.
NATURE REVIEWS IMMUNOLOGY (2015)
STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors
Seng-Ryong Woo et al.
IMMUNITY (2014)
STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors
Liufu Deng et al.
IMMUNITY (2014)
The role of TLR9 polymorphism in susceptibility to pulmonary tuberculosis
Deepak Bharti et al.
IMMUNOGENETICS (2014)
Antigen-Specific Immune Responses and Clinical Outcome After Vaccination With Glioma-Associated Antigen Peptides and Polyinosinic-Polycytidylic Acid Stabilized by Lysine and Carboxymethylcellulose in Children With Newly Diagnosed Malignant Brainstem and Nonbrainstem Gliomas
Ian F. Pollack et al.
JOURNAL OF CLINICAL ONCOLOGY (2014)
Endosomal Localization of TLR8 Confers Distinctive Proteolytic Processing on Human Myeloid Cells
Noriko Ishii et al.
JOURNAL OF IMMUNOLOGY (2014)
Inhibition of Dengue and Chikungunya Virus Infections by RIG-I-Mediated Type I Interferon-Independent Stimulation of the Innate Antiviral Response
David Olagnier et al.
JOURNAL OF VIROLOGY (2014)
Yeast Virus-Derived Stimulator of the Innate Immune System Augments the Efficacy of Virus Vector-Based Immunotherapy
Marie-Christine Claudepierre et al.
JOURNAL OF VIROLOGY (2014)
Hydrolysis of 2′3′-cGAMP by ENPP1 and design of nonhydrolyzable analogs
Lingyin Li et al.
NATURE CHEMICAL BIOLOGY (2014)
Cancer cell-autonomous contribution of type I interferon signaling to the efficacy of chemotherapy
Antonella Sistigu et al.
NATURE MEDICINE (2014)
The mechanism of action of BCG therapy for bladder cancer-a current perspective
Gil Redelman-Sidi et al.
NATURE REVIEWS UROLOGY (2014)
MyD88 and TLR9 Dependent Immune Responses Mediate Resistance to Leishmania guyanensis Infections, Irrespective of Leishmania RNA Virus Burden
Annette Ives et al.
PLOS ONE (2014)
Inflammation-driven carcinogenesis is mediated through STING
Jeonghyun Ahn et al.
NATURE COMMUNICATIONS (2014)
Genetic variations in Toll-like receptors (TLRs 3/7/8) are associated with systemic lupus erythematosus in a Taiwanese population
Chin-Man Wang et al.
SCIENTIFIC REPORTS (2014)
STING Contributes to Antiglioma Immunity via Triggering Type I IFN Signals in the Tumor Microenvironment
Takayuki Ohkuri et al.
CANCER IMMUNOLOGY RESEARCH (2014)
STING Ligand c-di-GMP Improves Cancer Vaccination against Metastatic Breast Cancer
Dinesh Chandra et al.
CANCER IMMUNOLOGY RESEARCH (2014)
Pattern recognition and signaling mechanisms of RIG-I and MDA5
Stephanie Reikine et al.
FRONTIERS IN IMMUNOLOGY (2014)
A long-awaited merger of the pathways mediating host defence and programmed cell death
J. Magarian Blander
NATURE REVIEWS IMMUNOLOGY (2014)
Assembly and localization of Toll-like receptor signalling complexes
Nicholas J. Gay et al.
NATURE REVIEWS IMMUNOLOGY (2014)
TLR7 Expression is Decreased During Tumour Progression in Transgenic Adenocarcinoma of Mouse Prostate Mice and Its Activation Inhibits Growth of Prostate Cancer Cells
Ju-Hee Han et al.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2013)
TLR8 stimulation enhances cetuximab-mediated natural killer cell lysis of head and neck cancer cells and dendritic cell cross-priming of EGFR-specific CD8+ T cells
Ryan M. Stephenson et al.
CANCER IMMUNOLOGY IMMUNOTHERAPY (2013)
Structure-Function Analysis of STING Activation by c[G(2′,5′) pA(3′,5′)p] and Targeting by Antiviral DMXAA
Pu Gao et al.
CELL (2013)
Cyclic [G(2′,5′) pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase
Pu Gao et al.
CELL (2013)
The eIF2α kinases: their structures and functions
Neysan Donnelly et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2013)
Sequential induction of type I and II interferons mediates a long-lasting gene induction in the liver in response to a novel toll-like receptor 9 agonist
Zuzanna Makowska et al.
JOURNAL OF HEPATOLOGY (2013)
Mouse, but not Human STING, Binds and Signals in Response to the Vascular Disrupting Agent 5,6-Dimethylxanthenone-4-Acetic Acid
Joseph Conlon et al.
JOURNAL OF IMMUNOLOGY (2013)
cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING
Andrea Ablasser et al.
NATURE (2013)
Structural mechanism of cytosolic DNA sensing by cGAS
Filiz Civril et al.
NATURE (2013)
Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP
Andrea Ablasser et al.
NATURE (2013)
Single Nucleotide Polymorphisms of Human STING Can Affect Innate Immune Response to Cyclic Dinucleotides
Guanghui Yi et al.
PLOS ONE (2013)
DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking
Takeshi Kondo et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway
Lijun Sun et al.
SCIENCE (2013)
Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects
Xiao-Dong Li et al.
SCIENCE (2013)
Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses
Daxing Gao et al.
SCIENCE (2013)
Aldara activates TLR7-independent immune defence
Anne Walter et al.
NATURE COMMUNICATIONS (2013)
Systems Analysis of a RIG-I Agonist Inducing Broad Spectrum Inhibition of Virus Infectivity
Marie-Line Goulet et al.
PLOS PATHOGENS (2013)
Targeting Toll-like receptors: promising therapeutic strategies for the management of sepsis-associated pathology and infectious diseases
Athina Savva et al.
FRONTIERS IN IMMUNOLOGY (2013)
A phase III randomized study of gemcitabine and cisplatin with or without PF-3512676 (TLR9 agonist) as first-line treatment of advanced non-small-cell lung cancer
C. Manegold et al.
ANNALS OF ONCOLOGY (2012)
Blocking Toll-Like Receptors 7 and 9 Reduces Postinterventional Remodeling via Reduced Macrophage Activation, Foam Cell Formation, and Migration
Jacco C. Karper et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2012)
R-848 triggers the expression of TLR7/8 and suppresses HIV replication in monocytes
Hua Nian et al.
BMC INFECTIOUS DISEASES (2012)
Toll-Like Receptor 7 Protects From Atherosclerosis by Constraining Inflammatory Macrophage Activation
Maria Salagianni et al.
CIRCULATION (2012)
VTX-2337 Is a Novel TLR8 Agonist That Activates NK Cells and Augments ADCC
Hailing Lu et al.
CLINICAL CANCER RESEARCH (2012)
Synergy of Topical Toll-like Receptor 7 Agonist with Radiation and Low-Dose Cyclophosphamide in a Mouse Model of Cutaneous Breast Cancer
M. Zahidunnabi Dewan et al.
CLINICAL CANCER RESEARCH (2012)
5,6-Dimethylxanthenone-4-acetic Acid (DMXAA) Activates Stimulator of Interferon Gene (STING)-dependent Innate Immune Pathways and Is Regulated by Mitochondrial Membrane Potential
Daniel Prantner et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Phase I clinical trial of CpG oligonucleotide 7909 (PF-03512676) in patients with previously treated chronic lymphocytic leukemia
Clive S. Zent et al.
LEUKEMIA & LYMPHOMA (2012)
Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure
Takafumi Oka et al.
NATURE (2012)
The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response
Kislay Parvatiyar et al.
NATURE IMMUNOLOGY (2012)
Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape
Bradley N. Bidwell et al.
NATURE MEDICINE (2012)
An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration
Sabrina M. Lehmann et al.
NATURE NEUROSCIENCE (2012)
Modulating immunity as a therapy for bacterial infections
Robert E. W. Hancock et al.
NATURE REVIEWS MICROBIOLOGY (2012)
A Double-Blind, Placebo-Controlled, Randomized, Clinical Trial of the TLR-3 Agonist Rintatolimod in Severe Cases of Chronic Fatigue Syndrome
David R. Strayer et al.
PLOS ONE (2012)
Investigation of the role of endosomal Toll-like receptors in murine collagen-induced arthritis reveals a potential role for TLR7 in disease maintenance
Saba Alzabin et al.
ARTHRITIS RESEARCH & THERAPY (2012)
DNA-PK is a DNA sensor for IRF-3-dependent innate immunity
Brian J. Ferguson et al.
ELIFE (2012)
Accessory molecules for Toll-like receptors and their function
Clarissa C. Lee et al.
NATURE REVIEWS IMMUNOLOGY (2012)
MyD88 Deficiency Ameliorates β-Amyloidosis in an Animal Model of Alzheimer's Disease
Jeong-Eun Lim et al.
AMERICAN JOURNAL OF PATHOLOGY (2011)
CpG Blocks Immunosuppression by Myeloid-Derived Suppressor Cells in Tumor-Bearing Mice
Christine Zoglmeier et al.
CLINICAL CANCER RESEARCH (2011)
Toll-like receptor 3, RIG-I-like receptors and the NLRP3 inflammasome: Key modulators of innate immune responses to double-stranded RNA viruses
Man Yu et al.
CYTOKINE & GROWTH FACTOR REVIEWS (2011)
Pivotal Role of Dermal IL-17-Producing γδ T Cells in Skin Inflammation
Yihua Cai et al.
IMMUNITY (2011)
Randomized Phase III Placebo-Controlled Trial of Carboplatin and Paclitaxel With or Without the Vascular Disrupting Agent Vadimezan (ASA404) in Advanced Non-Small-Cell Lung Cancer
Primo N. Lara et al.
JOURNAL OF CLINICAL ONCOLOGY (2011)
Randomized Phase III Trial of Paclitaxel/Carboplatin With or Without PF-3512676 (Toll-Like Receptor 9 Agonist) As First-Line Treatment for Advanced Non-Small-Cell Lung Cancer
Vera Hirsh et al.
JOURNAL OF CLINICAL ONCOLOGY (2011)
STING is a direct innate immune sensor of cyclic di-GMP
Dara L. Burdette et al.
NATURE (2011)
Microglial glucocorticoid receptors play a pivotal role in regulating dopaminergic neurodegeneration in parkinsonism
Francisco Ros-Bernal et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Antiviral responses induced by the TLR3 pathway
Misako Matsumoto et al.
REVIEWS IN MEDICAL VIROLOGY (2011)
Therapeutic Targeting of TLR9 Inhibits Cell Growth and Induces Apoptosis in Neuroblastoma
Chiara Brignole et al.
CANCER RESEARCH (2010)
Phase II Study on the Addition of ASA404 (Vadimezan; 5,6-Dimethylxanthenone-4-Acetic Acid) to Docetaxel in CRMPC
Roberto Pili et al.
CLINICAL CANCER RESEARCH (2010)
Alternating 2′-O-ribose methylation is a universal approach for generating non-stimulatory siRNA by acting as TLR7 antagonist
Svetlana Hamm et al.
IMMUNOBIOLOGY (2010)
TLR9 Regulates TLR7-and MyD88-Dependent Autoantibody Production and Disease in a Murine Model of Lupus
Kevin M. Nickerson et al.
JOURNAL OF IMMUNOLOGY (2010)
Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry
Leonardo H. Travassos et al.
NATURE IMMUNOLOGY (2010)
Targeting Toll-like receptors: emerging therapeutics?
Elizabeth J. Hennessy et al.
NATURE REVIEWS DRUG DISCOVERY (2010)
Intracerebral administration of CpG oligonucleotide for patients with recurrent glioblastoma: a phase II study
Alexandre Carpentier et al.
NEURO-ONCOLOGY (2010)
Contrasting Roles for TLR Ligands in HIV-1 Pathogenesis
Beda Brichacek et al.
PLOS ONE (2010)
Genome-Wide Association Study in Asian Populations Identifies Variants in ETS1 and WDFY4 Associated with Systemic Lupus Erythematosus
Wanling Yang et al.
PLOS GENETICS (2010)
T-cell modulation combined with intratumoral CpG cures lymphoma in a mouse model without the need for chemotherapy
Roch Houot et al.
BLOOD (2009)
Randomized Phase 2/3 Trial of CpG Oligodeoxynucleotide PF-3512676 Alone or With Dacarbazine for Patients With Unresectable Stage III and IV Melanoma
Jeffrey S. Weber et al.
CANCER (2009)
Targeted Activation of Innate Immunity for Therapeutic Induction of Autophagy and Apoptosis in Melanoma Cells
Damia Tormo et al.
CANCER CELL (2009)
RNA Polymerase III Detects Cytosolic DNA and Induces Type I Interferons through the RIG-I Pathway
Yu-Hsin Chiu et al.
CELL (2009)
Safety and Efficacy of PF-3512676 for the Treatment of Stage IV Renal Cell Carcinoma: An Open-Label, Multicenter Phase I/II Study
John A. Thompson et al.
CLINICAL GENITOURINARY CANCER (2009)
CHLAMYDIA PNEUMONIAE AND ATHEROSCLEROSIS: CURRENT STATE AND FUTURE PROSPECTIVES
R. Sessa et al.
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY (2009)
Polymorphisms and haplotypes in TLR9 and MYD88 are associated with the development of Hodgkin's lymphoma: a candidate-gene association study
Vassiliki Mollaki et al.
JOURNAL OF HUMAN GENETICS (2009)
Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice Is Mediated via the IL-23/IL-17 Axis
Leslie van der Fits et al.
JOURNAL OF IMMUNOLOGY (2009)
Reversal of Human Papillomavirus-Specific T Cell Immune Suppression through TLR Agonist Treatment of Langerhans Cells Exposed to Human Papillomavirus Type 16
Laura M. Fahey et al.
JOURNAL OF IMMUNOLOGY (2009)
AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
Veit Hornung et al.
NATURE (2009)
Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus
Dwight H. Kono et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
A clinical grade poly I:C-analogue (Ampligen (R)) promotes optimal DC maturation and Th1-type T cell responses of healthy donors and cancer patients in vitro
H. Navabi et al.
VACCINE (2009)
DNA-like class R inhibitory oligonucleotides (INH-ODNs) preferentially block autoantigen-induced B-cell and dendritic cell activation in vitro and autoantibody production in lupus-prone MRL-Fas(lpr/lpr) mice in vivo
Petar Lenert et al.
ARTHRITIS RESEARCH & THERAPY (2009)
Overexpression of Toll-like Receptors 3 and 4 in Synovial Tissue From Patients With Early Rheumatoid Arthritis Toll-like Receptor Expression in Early and Longstanding Arthritis
Caroline Ospelt et al.
ARTHRITIS AND RHEUMATISM (2008)
CPG 7909 adjuvant plus hepatitis B virus vaccination in HIV-infected adults achieves long-term seroprotection for up to 5 years
C. L. Cooper et al.
CLINICAL INFECTIOUS DISEASES (2008)
Randomized phase II trial of a toll-like receptor 9 agonist oligodeoxynucleotide, PF-3512676, in combination with first-line taxane plus platinum chemotherapy for advanced-stage non-small-cell lung cancer
Christian Manegold et al.
JOURNAL OF CLINICAL ONCOLOGY (2008)
Identification of RNA sequence motifs stimulating sequence-specific TLR8-dependent immune responses
Alexandra Forsbach et al.
JOURNAL OF IMMUNOLOGY (2008)
5′-triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma
Hendrik Poeck et al.
NATURE MEDICINE (2008)
Interferon signaling and treatment outcome in chronic hepatitis C
Magdalena Sarasin-Filipowicz et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
The Drosophila systemic immune response:: sensing and signalling during bacterial and fungal infections
Dominique Ferrandon et al.
NATURE REVIEWS IMMUNOLOGY (2007)
Control of toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferation
Jonathan A. Deane et al.
IMMUNITY (2007)
Phase I trial of toll-like receptor 9 agonist PF-3512676 with and following rituximab in patients with recurrent indolent and aggressive non-hodgkin's lymphoma
John R. Leonard et al.
CLINICAL CANCER RESEARCH (2007)
Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 are associated with systemic lupus erythematosus
Min Ae Lee-Kirsch et al.
NATURE GENETICS (2007)
Investigating toll-like receptor agonists for potential to treat hepatitis C virus infection
Amy Thomas et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2007)
Oral resiquimod in chronic HCV infection: Safety and efficacy in 2 placebo-controlled, double-blind phase IIa studies
Paul J. Pockros et al.
JOURNAL OF HEPATOLOGY (2007)
TLR9 agonist acts by different mechanisms synergizing with bevacizumab in sensitive and cetuximab-resistant colon cancer xenografts
Vincenzo Damiano et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Topical resiquimod 0.01% gel decreases herpes simplex virus type 2 genital shedding: A randomized, controlled trial
Karen E. Mark et al.
JOURNAL OF INFECTIOUS DISEASES (2007)
Phase II trial of a Toll-like receptor 9-activating oligonucleotide in patients with metastatic melanoma
Mikhail Pashenkov et al.
JOURNAL OF CLINICAL ONCOLOGY (2006)
5′-triphosphate RNA is the ligand for RIG-I
Veit Hornung et al.
SCIENCE (2006)
Expansion of toll-like receptor 9-expressing B cells in active systemic lupus erythematosus - Implications for the induction and maintenance of the autoimmune process
Eva D. Papadimitraki et al.
ARTHRITIS AND RHEUMATISM (2006)
Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus
Sean R. Christensen et al.
IMMUNITY (2006)
Toll-like receptor 7-dependent loss of B cell tolerance in pathogenic autoantibody knockin mice
Robert Berland et al.
IMMUNITY (2006)
Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 cause Aicardi-Goutieres syndrome at the AGS1 locus
Yanick J. Crow et al.
NATURE GENETICS (2006)
A Tlr7 translocation accelerates systemic autoimmunity in murine lupus
Srividya Subramanian et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
TLR7 ligand prevents allergen-induced airway hyperresponsiveness and eosinophilia in allergic asthma by a MYD88-dependent and MK2-independent pathway
J Moisan et al.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2006)
TLR signaling
T Kawai et al.
CELL DEATH AND DIFFERENTIATION (2006)
TLR3 can directly trigger apoptosis in human cancer cells
Bruno Salaun et al.
JOURNAL OF IMMUNOLOGY (2006)
5,6-Dimethylxanthenone-4-acetic acid in the treatment of refractory tumors: a phase I safety study of a vascular disrupting agent
M McKeage et al.
CLINICAL CANCER RESEARCH (2006)
Cryopyrin activates the inflammasome in response to toxins and ATP
S Mariathasan et al.
NATURE (2006)
Innate immunity mediated by TLR9 modulates pathogenicity in an animal model of multiple sclerosis
M Prinz et al.
JOURNAL OF CLINICAL INVESTIGATION (2006)
Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8
J Vollmer et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2005)
The toll-like receptor 7 (TLR7) agonist, imiquimod, and the TLR9 agonist, CpG ODN, induce antiviral cytokines and chemokines but do not prevent vaginal transmission of simian immunodeficiency virus when applied intravaginally to rhesus macaques
YC Wang et al.
JOURNAL OF VIROLOGY (2005)
The Expression of toll-like receptors 3 and 7 in rheumatoid arthritis synovium is increased and costimulation of toll-like receptors 3, 4, and 7/8 results in synergistic cytokine production by dendritic cells
MF Roelofs et al.
ARTHRITIS AND RHEUMATISM (2005)
Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus
SR Christensen et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2005)
Synthesis and structure-activity-relationships of 1H-imidazo[4,5-c]quinolines that induce interferon production
JF Gerster et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Immunomodulatory oligonucleotides containing a cytosine-phosphate-2'-deoxy-7-deazaguanosine motif as potent toll-like receptor 9 agonists
ER Kandimalla et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Viral double-stranded RNA aggravates lupus nephritis through toll-like receptor 3 on glomerular mesangial cells and antigen-presenting cells
PS Patole et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2005)
Toll-like receptor 2 stimulation induces intimal hyperplasia and atherosclerotic lesion development
AH Schoneveld et al.
CARDIOVASCULAR RESEARCH (2005)
Toll-like receptor 3 promotes cross-priming to virus-infected cells
O Schulz et al.
NATURE (2005)
Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways
H Björkbacka et al.
NATURE MEDICINE (2004)
Signaling through toll-like receptors triggers HIV-1 replication in latently infected mast cells
JB Sundstrom et al.
JOURNAL OF IMMUNOLOGY (2004)
Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
SS Diebold et al.
SCIENCE (2004)
Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8
F Heil et al.
SCIENCE (2004)
Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E
KS Michelsen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses
M Yoneyama et al.
NATURE IMMUNOLOGY (2004)
Intratumor CpG-oligodeoxynucleotide injection induces protective antitumor T cell immunity
AS Lonsdorf et al.
JOURNAL OF IMMUNOLOGY (2003)
Toll-like receptor 2 (TLR2) and TLR9 signaling results in HIV-long terminal repeat trans-activation and HIV replication in HIV-1 transgenic mouse spleen cells:: Implications of simultaneous activation of TLRs on HIV replication
O Equils et al.
JOURNAL OF IMMUNOLOGY (2003)
Cutting edge:: A novel toll/IL-1 receptor Domain containing adapter that preferentially activates the IFN-β promoter in the toll-like receptor signaling
M Yamamoto et al.
JOURNAL OF IMMUNOLOGY (2002)
Effective postexposure treatment of retrovirus-induced disease with immunostimulatory DNA containing CpG motifs
ARM Olbrich et al.
JOURNAL OF VIROLOGY (2002)
In vivo evidence for a role of toll-like receptor 4 in the development of intimal lesions
A Vink et al.
CIRCULATION (2002)
Toll-like receptors as potential therapeutic targets for multiple diseases
C Zuany-Amorim et al.
NATURE REVIEWS DRUG DISCOVERY (2002)
Peritumoral CpG DNA elicits a coordinated response of CD8 T cells and innate effectors to cure established tumors in a murine colon carcinoma model
K Heckelsmiller et al.
JOURNAL OF IMMUNOLOGY (2002)
Transcript mutations of the a regulatory subunit of protein kinase A and up-regulation of the RNA-editing gene transcript in lupus T lymphocytes
D Laxminarayana et al.
LANCET (2002)
Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway
H Hemmi et al.
NATURE IMMUNOLOGY (2002)
Toll-like receptors: critical proteins linking innate and acquired immunity
S Akira et al.
NATURE IMMUNOLOGY (2001)
A Toll-like receptor recognizes bacterial DNA
H Hemmi et al.
NATURE (2000)
Share Paper
