Journal
NATURE NEUROSCIENCE
Volume 22, Issue 10, Pages 1709-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41593-019-0465-5
Keywords
-
Categories
Funding
- SIB (Swiss Institute of Bioinformatics)
- Life Science Training Facility
- Quantitative Genomics Facility Basel
- Boehringer Ingelheim PhD Fonds
- Doris Dietschy Stiftung
- Swiss National Science Foundation
- European Research Council Advanced Grant (SPLICECODE)
- Kanton Basel-Stadt
Ask authors/readers for more resources
Nervous system function relies on complex assemblies of distinct neuronal cell types that have unique anatomical and functional properties instructed by molecular programs. Alternative splicing is a key mechanism for the expansion of molecular repertoires, and protein splice isoforms shape neuronal cell surface recognition and function. However, the logic of how alternative splicing programs are arrayed across neuronal cells types is poorly understood. We systematically mapped ribosome-associated transcript isoforms in genetically defined neuron types of the mouse forebrain. Our dataset provides an extensive resource of transcript diversity across major neuron classes. We find that neuronal transcript isoform profiles reliably distinguish even closely related classes of pyramidal cells and inhibitory interneurons in the mouse hippocampus and neocortex. These highly specific alternative splicing programs selectively control synaptic proteins and intrinsic neuronal properties. Thus, transcript diversification via alternative splicing is a central mechanism for the functional specification of neuronal cell types and circuits.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available