Journal
NATURE NANOTECHNOLOGY
Volume 14, Issue 9, Pages 858-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41565-019-0514-y
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Funding
- National Human Genome Research Institute of the National Institutes of Health [R01-HG007406]
- National Science Foundation [DMR-0955959]
- Oxford Nanopore Technologies
- XSEDE [MCA05S028]
- Netherlands Organization for Scientific Research (NWO)
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Precision placement and transport of biomolecules are critical to many single-molecule manipulation and detection methods. One such method is nanopore sequencing, in which the delivery of biomolecules towards a nanopore controls the method's throughput. Using all-atom molecular dynamics, here we show that the precision transport of biomolecules can be realized by utilizing ubiquitous features of graphene surface-step defects that separate multilayer domains. Subject to an external force, we found that adsorbed DNA moved much faster down a step defect than up, and even faster along the defect edge, regardless of whether the motion was produced by a mechanical force or a solvent flow. We utilized this direction dependency to demonstrate a mechanical analogue of an electric diode and a system for delivering DNA molecules to a nanopore. The defect-guided delivery principle can be used for the separation, concentration and storage of scarce biomolecular species, on-demand chemical reactions and nanopore sensing.
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