Journal
NATURE METHODS
Volume 16, Issue 10, Pages 994-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41592-019-0572-y
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Funding
- European Research Council under the European Union's Seventh Framework Program/ERC Advanced grant [FP7/2007-2013, 339244-FUSIMAGINE]
- Human Brain Project [FUSIMICE ANR-15-HBPR-0004]
- AXA Research Fund
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We extended the capabilities of functional ultrasound to whole-brain four-dimensional (4D) neuroimaging. Our multiplane-wave transmission scheme on matrix arrays at thousands of frames per second provides volumetric recordings of cerebral blood volume changes at high spatiotemporal resolution. We illustrated the approach in rats while providing multiple sensory stimuli, for 4D functional connectivity and during instantaneous tracking of epileptiform events.
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