Journal
NATURE GENETICS
Volume 51, Issue 9, Pages 1330-+Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41588-019-0483-y
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Funding
- Wellcome Trust [100956/Z/13/Z]
- Rhodes Trust
- Health Data Research UK
- NIHR Oxford Biomedical Research Centre
- Wellcome Trust [100956/Z/13/Z] Funding Source: Wellcome Trust
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Inferring the full genealogical history of a set of DNA sequences is a core problem in evolutionary biology, because this history encodes information about the events and forces that have influenced a species. However, current methods are limited, and the most accurate techniques are able to process no more than a hundred samples. As datasets that consist of millions of genomes are now being collected, there is a need for scalable and efficient inference methods to fully utilize these resources. Here we introduce an algorithm that is able to not only infer whole-genome histories with comparable accuracy to the stateof-the-art but also process four orders of magnitude more sequences. The approach also provides an 'evolutionary encoding' of the data, enabling efficient calculation of relevant statistics. We apply the method to human data from the 1000 Genomes Project, Simons Genome Diversity Project and UK Biobank, showing that the inferred genealogies are rich in biological signal and efficient to process.
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