4.8 Article

A global overview of pleiotropy and genetic architecture in complex traits

Related references

Note: Only part of the references are listed.
Article Multidisciplinary Sciences

Bivariate causal mixture model quantifies polygenic overlap between complex traits beyond genetic correlation

Oleksandr Frei et al.

NATURE COMMUNICATIONS (2019)

Article Genetics & Heredity

SumHer better estimates the SNP heritability of complex traits from summary statistics

Doug Speed et al.

NATURE GENETICS (2019)

Review Genetics & Heredity

Genetic architecture: the shape of the genetic contribution to human traits and disease

Nicholas J. Timpson et al.

NATURE REVIEWS GENETICS (2018)

Review Biochemistry & Molecular Biology

Common Disease Is More Complex Than Implied by the Core Gene Omnigenic Model

Naomi R. Wray et al.

Article Multidisciplinary Sciences

The UK Biobank resource with deep phenotyping and genomic data

Clare Bycroft et al.

NATURE (2018)

Article Genetics & Heredity

An atlas of genetic associations in UK Biobank

Oriol Canela-Xandri et al.

NATURE GENETICS (2018)

Article Multidisciplinary Sciences

Genetic effects on gene expression across human tissues

Francois Aguet et al.

NATURE (2017)

Article Genetics & Heredity

Reevaluation of SNP heritability in complex human traits

Doug Speed et al.

NATURE GENETICS (2017)

Article Multidisciplinary Sciences

Functional mapping and annotation of genetic associations with FUMA

Kyoko Watanabe et al.

NATURE COMMUNICATIONS (2017)

Article Genetics & Heredity

Prospects of Fine-Mapping Trait-Associated Genomic Regions by Using Summary Statistics from Genome-wide Association Studies

Christian Benner et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2017)

Review Genetics & Heredity

10 Years of GWAS Discovery: Biology, Function, and Translation

Peter M. Visscher et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2017)

Review Biochemistry & Molecular Biology

An Expanded View of Complex Traits: From Polygenic to Omnigenic

Evan A. Boyle et al.

Article Biochemical Research Methods

FINEMAP: efficient variable selection using summary data from genome-wide association studies

Christian Benner et al.

BIOINFORMATICS (2016)

Article Multidisciplinary Sciences

Analysis of protein-coding genetic variation in 60,706 humans

Monkol Lek et al.

NATURE (2016)

Article Multidisciplinary Sciences

Integrative analysis of 111 reference human epigenomes

Anshul Kundaje et al.

NATURE (2015)

Article Multidisciplinary Sciences

A global reference for human genetic variation

David M. Altshuler et al.

NATURE (2015)

Article Genetics & Heredity

Meta-analysis of the heritability of human traits based on fifty years of twin studies

Tinca J. C. Polderman et al.

NATURE GENETICS (2015)

Article Genetics & Heredity

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

Brendan K. Bulik-Sullivan et al.

NATURE GENETICS (2015)

Article Biochemical Research Methods

MAGMA: Generalized Gene-Set Analysis of GWAS Data

Christiaan A. de Leeuw et al.

PLOS COMPUTATIONAL BIOLOGY (2015)

Article Genetics & Heredity

Evaluating the Performance of Fine-Mapping Strategies at Common Variant GWAS Loci

Martijn van de Bunt et al.

PLOS GENETICS (2015)

Review Genetics & Heredity

Rare-Variant Association Analysis: Study Designs and Statistical Tests

Seunggeung Lee et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2014)

Article Multidisciplinary Sciences

Genetics of rheumatoid arthritis contributes to biology and drug discovery

Yukinori Okada et al.

NATURE (2014)

Article Biochemistry & Molecular Biology

The NHGRI GWAS Catalog, a curated resource of SNP-trait associations

Danielle Welter et al.

NUCLEIC ACIDS RESEARCH (2014)

Review Genetics & Heredity

Pleiotropy in complex traits: challenges and strategies

Nadia Solovieff et al.

NATURE REVIEWS GENETICS (2013)

Article Cell Biology

The Role of Autophagy in Crohn’s Disease

Paul Henderson et al.

Cells (2012)

Article Biochemical Research Methods

Molecular signatures database (MSigDB) 3.0

Arthur Liberzon et al.

BIOINFORMATICS (2011)

Review Multidisciplinary Sciences

Initial impact of the sequencing of the human genome

Eric S. Lander

NATURE (2011)

Article Biochemistry & Molecular Biology

ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data

Kai Wang et al.

NUCLEIC ACIDS RESEARCH (2010)

Review Multidisciplinary Sciences

Finding the missing heritability of complex diseases

Teri A. Manolio et al.

NATURE (2009)

Article Genetics & Heredity

PLINK: A tool set for whole-genome association and population-based linkage analyses

Shaun Purcell et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2007)

Article Multidisciplinary Sciences

The human disease network

Kwang-Il Goh et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Multidisciplinary Sciences

Complement factor H polymorphism and age-related macular degeneration

AO Edwards et al.

SCIENCE (2005)