Journal
NATURE CELL BIOLOGY
Volume 21, Issue 9, Pages 1068-1077Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41556-019-0379-1
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Funding
- NIH [R01GM117376]
- NSF Career [1751197]
- DFG [GR 2111/7-1]
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [1751197] Funding Source: National Science Foundation
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Recent development of innovative tools for live imaging of actin filaments (F-actin) enabled the detection of surprising nuclear structures responding to various stimuli, challenging previous models that actin is substantially monomeric in the nucleus. We review these discoveries, focusing on double-strand break (DSB) repair responses. These studies revealed a remarkable network of nuclear filaments and regulatory mechanisms coordinating chromatin dynamics with repair progression and led to a paradigm shift by uncovering the directed movement of repair sites.
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